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GI Bleed Hospitalization Risk Linked to Oral Anticoagulant Choice, PPI Cotherapy

To compare the incidence of hospitalization for upper GI tract bleeding, researchers used US Medicare beneficiary files to identify a cohort of patients that were ≥30 years old who initiated oral anticoagulation therapy with apixaban, dabigatran, rivaroxaban, or warfarin, with or without PPI cotherapy.

Antibiotics, Acid Suppressants in Infancy May Up Obesity Risk

The researchers found that 72.4, 11.8, and 3.3% of children were prescribed an antibiotic, an H2RA, and a PPI, respectively. There was an association between antibiotic prescriptions and obesity (hazard ratio, 1.26).

Review: Managing Patients With Refractory Heartburn

Patients with functional heartburn display similar symptoms seen in GERD and most often complain of a burning retrosternal discomfort. Once the underlying cause of a patient's refractory heartburn is determined, appropriate therapy can be initiated.

Diet May Be as Effective as PPIs in Reducing Reflux Symptoms

In this retrospective study, researchers from New York Medical College, Valhalla, NY, compared the efficacy of diet-based treatment consisting of alkaline water (pH >8.0) and plant-based Mediterranean-style diet vs. the conventional PPI approach.

AGA: Best Practices for Prescribing PPIs

While the benefits of treatment should be weighed against the risks on an individual basis, the AGA has provided recommendations to help clinicians make treatment decisions with regards to PPI use.