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GI Bleed Hospitalization Risk Linked to Oral Anticoagulant Choice, PPI Cotherapy

To compare the incidence of hospitalization for upper GI tract bleeding, researchers used US Medicare beneficiary files to identify a cohort of patients that were ≥30 years old who initiated oral anticoagulation therapy with apixaban, dabigatran, rivaroxaban, or warfarin, with or without PPI cotherapy.
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AGA: Best Practices for Prescribing PPIs

While the benefits of treatment should be weighed against the risks on an individual basis, the AGA has provided recommendations to help clinicians make treatment decisions with regards to PPI use.