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Exploratory Data Show Additional Benefits of Vedolizumab in Ulcerative Colitis

New exploratory data published in the New England Journal of Medicine further provide evidence of the benefits of vedolizumab (Entyvio; Takeda), an integrin receptor antagonist, when compared with adalimumab (Humira; AbbVie), a tumor necrosis factor-alpha (TNFα) antagonist, in patients with moderately to severely active ulcerative colitis.   In the phase 3b VARSITY study, patients were randomized…
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How I Treat: Hidradenitis Suppurativa

Hidradenitis suppurativa (HS) is classified as a progressive, inflammatory disease that appears to be primarily caused by inflammation of hair follicles and is most often found in areas of friction of the body, such as the axillae, groin, perineum, and medial thighs. The inflammation associated with HS presents clinically with recurrent inflamed painful nodules and…
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Dupilumab Safe, Effective in Pediatric Atopic Dermatitis Trial

Topline results from a phase 3 study investigating dupilumab in the treatment of pediatric patients with severe atopic dermatitis showed that the interleukin-4 receptor alpha antagonist was both safe and effective in this patient population.
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Dupixent Approved for Chronic Rhinosinusitis With Nasal Polyps

The Food and Drug Administration (FDA) has approved Dupixent (dupilumab; Sanofi and Regeneron) as an add-on maintenance treatment in adult patients with inadequately controlled chronic rhinosinusitis with nasal polyposis (CRSwNP). The approval was based on data from two phase 3 randomized, double blind, placebo controlled trials (SINUS-24 and SINUS-52) that evaluated the safety and efficacy…