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Overview On March 11, 2020, the World Health Organization (WHO) declared a global pandemic of a novel respiratory coronavirus, now known as SARS-CoV-2.1 Rapid spread of the original virus and its multiple variants led to more than 1 million deaths in the United States and nearly 7 million deaths worldwide by the time the WHO…

While naloxone, a short-acting opioid antagonist, has become the standard treatment for opioid overdose, there are situations where longer-acting opioid antagonists are a more appropriate treatment choice, especially considering the rise of fentanyl. In this article, Dr Adam Bisaga, professor of psychiatry at the Columbia University Irving Medical Center in New York and research scientist at the New York State Psychiatric Institute, discusses various clinical considerations in the treatment of opioid overdose and opioid use disorder.