Apixaban is a substrate of P-glycoprotein and P-glycoprotein inhibition increases drug exposure.
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Older patients, females, and those with comorbidities were more likely to be on multiple medications.
ANNEXA-4 is a global, single-arm, open-label clinical trial designed to evaluate andexanet alfa in patients who present with an acute major bleed while receiving apixaban, rivaroxaban, edoxaban or enoxaparin.
End-stage renal disease patients on dialysis with atrial fibrillation are at high risk for thrombotic complications.