First FDA-approved oral liquid dosage form of the potassium-sparing diuretic spironolactone.
Several sub-studies investigated the superior efficacy of spironolactone in RHTN and whether there was potential benefit with amiloride in the same population.
CaroSpir, an aldosterone antagonist, works primarily through competitive binding of receptors at the aldosterone-dependent sodium-potassium exchange site in the distal convoluted renal tube.
Among eligible patients with heart failure and reduced ejection fraction (HFrEF), use of spironolactone was associated with improved clinical outcomes.
To date, there have been no reports of any adverse events related to this recall.
Recent data regarding the treatment of premenstrual syndrome/premenstrual dysphoric disorder (PMS/PMDD) has "triaged therapy options into first, second, third, and last lines."
MRAs such as spironolactone and eplerenone are "still underused in routine clinical practice" but can be effective in countering the harms of high aldosterone levels, explained study author Professor Farzin Beygui, MD, PhD.
Researchers from the University of Florida analyzed the use of antihypertensive drugs among patients with treatment-resistant hypertension and found "persistent infrequent use" of recommended treatments.
The safety and efficacy of topical minoxidil for the treatment of female pattern hair loss was supported by moderate to low quality evidence in a recent Cochrane systematic review.
For patients with resistant hypertension, adding spironolactone was significantly more effective than adding other antihypertensives, researchers presented at the European Society of Cardiology Congress 2015.