Investigators report results from a systematic review and meta-analysis of data from 23 randomized controlled trials involving 15,144 patients with anemia of CKD.
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Study findings do not support initiation of uric acid-lowering therapy to prevent CKD.
The systematic review and meta-analysis included a broad range of patients with and without chronic kidney disease.
This study raises important questions about the choice between lactated Ringer and saline.
Uncertainty regarding diuretic efficacy and optimal dosing in hemodialysis likely contributes to practice variation, according to investigators.
Study findings highlight an “unmet need” for newer therapies.