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Study is the largest to explore this potential safety issue to date.
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The most common inappropriate medications included proton pump inhibitors, alpha blockers, and NSAIDs.
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Avoiding inappropriate use and overdosing of drugs with nephrotoxic effects is an important strategy to prevent hospital-acquired AKI in children, according to investigators.
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Prompt diagnosis of AKI and the ability to rule out immune checkpoint inhibitors as the cause may allow patients to continue with cancer immunotherapy.
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In a real-world study, 3% of AKI events potentially related to use of immune checkpoint inhibitor therapy -- a higher rate than reported in clinical trials.