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The Food and Drug Administration (FDA) has issued warning letters to fourteen manufacturers of dietary supplements due to the listing of 1,3-Dimethylbutylamine (also known as DMBA, 2-amino-4-methylpentane, AMP citrate, and 4-methyl-2-pentanamine) on the product label.

Amphetamine-like analogues as a short term adjunct in management of exogenous obesity have several absolute contraindications like history of cardiovascular disease and hyperthyroidism, but not diabetes. A case study in Case Reports in Endocrinology describes a patient with a history of type 1 diabetes who experienced diabetic ketoacidosis (DKA) after starting diethylpropion HCI for weight loss.