For warfarin-treated patients, carbamazepine co-treatment is associated with subtherapeutic anticoagulative effect and increased warfarin dose requirements, according to a study published online in the Journal of Thrombosis and Haemostasis.
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Linked to lower risk of intracranial bleeding, but higher risk of gastrointestinal bleeding
About 20% of patients administered fresh frozen plasma (FFP) to reverse warfarin anticoagulation develop pulmonary complications, with highest risk seen with more than three units of FFP, according to a study published online December 8 in the Journal of Thrombosis and Haemostasis.
More frequent monitoring may be required when patients are taking both acenocoumarol and levofloxacin due to the possibility of an adverse interaction, according to a case report published in the December issue of the Journal of Clinical Pharmacy and Therapeutics.
Taking warfarin at the same time as glipizide or glimepiride may increase the risk of hospitalization, according to a study published online December 7 in The BMJ.
Despite trend toward lower stroke risk with high dose
For many Canadian patients with atrial fibrillation, primary care physicians do not provide stroke or bleeding risk estimates.
For patients on warfarin, an anticoagulation report that is embedded in the discharge summary has no impact on clinical outcomes, although it is perceived to improve patient safety.
Among hospitalized patients, high-dose amoxicillin/clavulanate correlates with increased risk of over-anticoagulation when combined with warfarin.
Pharmacist-managed warfarin therapy (PMWT) is superior to a usual medical care (UMC) model for management of warfarin therapy, according to a new review.