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The U.S. Preventive Services Task Force has found that there is currently insufficient evidence to recommend primary care interventions to prevent or reduce illicit drug use or nonmedical prescription drug use among youth.

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For adolescents and young adults with autism spectrum disorders, few studies have assessed treatment approaches, and there is limited evidence available to support specific interventions, with most available studies of poor quality.

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Evidence is lacking for the associations between vitamin D and health outcomes in one study, but another found that lower levels of circulating 25-hydroxyvitamin D correlate with increased mortality.