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The approval was based on data from the LIGHTHOUSE and SPOTLIGHT clinical trials.

Greater improvements seen for blood pressure, blood sugar levels, and weight control versus DASH diet.

The increasing number of indications for second-generation antiandrogens may result in a large group of men at risk for toxic effects.

Strong recommendations made for use of polyethylene glycol, sodium picosulfate, linaclotide, plecanatide, and prucalopride.