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Investigators report results from a systematic review and meta-analysis of data from 23 randomized controlled trials involving 15,144 patients with anemia of CKD.

Study findings do not support initiation of uric acid-lowering therapy to prevent CKD.

The systematic review and meta-analysis included a broad range of patients with and without chronic kidney disease.

Uncertainty regarding diuretic efficacy and optimal dosing in hemodialysis likely contributes to practice variation, according to investigators.

Reviewers discussed new and conventional therapies for lupus nephritis and the prospect of precision medicine.