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Proton Pump Inhibitor Use May Up Death Risk

The authors found that compared to the use of H2RA therapy, patients initiated on PPI therapy had a 25% increased risk of death (hazard ratio [HR] 1.25, 95% CI: 1.23-1.28).

Myopathy: Another Side Effect of PPIs?

Limited research published in Annals of Pharmacotherapy suggests that use of proton pump inhibitors (PPI) is associated with myopathy-like symptoms without long-term effects after discontinuation.

Are PPI Users at Risk for Vitamin B12 Deficiency?

Proton pump inhibitors (PPIs) were associated with a higher risk of inducing vitamin B12 deficiency than histamine-2 receptor antagonists (H2RAs) but longer prospective studies are needed to confirm this finding, study authors concluded in the Journal of Pharmacy Practice.

Common GERD Meds May Speed Up Vascular Aging

A team of researchers from Houston Methodist Research Institute reported that chronic use of proton pump inhibitors (PPIs) may accelerate vascular aging, which can lead to greater cardiovascular disease, vascular dementia, and renal failure.

Some Antacids Linked to Heart Attack Risk

Use of proton pump inhibitors (PPIs) increase the risk of an adult experiencing a heart attack by 16 to 21 percent compared to those who don't use commonly prescribed antacids, a large study has found.

Infant PPI Use and Lung Infection Risk: Is There a Link?

The data showed matched odds ratio for current vs past use of PPIs to be 0.88 (95% CI, 0.36 to 2.16) when comparing cases and their controls for community-acquired pneumonia. With regard to lower respiratory tract infections, the matched odds ratio between cases and their controls was 1.13 (95% CI, 0.87 to 1.48).