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The data showed matched odds ratio for current vs past use of PPIs to be 0.88 (95% CI, 0.36 to 2.16) when comparing cases and their controls for community-acquired pneumonia. With regard to lower respiratory tract infections, the matched odds ratio between cases and their controls was 1.13 (95% CI, 0.87 to 1.48).
Generics News
Omeprazole ODT utilizes MelTech technology that allows the tablet to dissolve in the mouth without water.
ACC.18
The primary efficacy outcome was the combined rate of death from a cardiovascular cause, heart attack, stroke due to inadequate blood supply, blood clots or amputation due to cardiovascular disease.
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Prezcobix, a combination of an HIV-1 protease inhibitor and a CYP3A inhibitor, is indicated to treat HIV-1 infection in adults.
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In this retrospective study, researchers from New York Medical College, Valhalla, NY, compared the efficacy of diet-based treatment consisting of alkaline water (pH >8.0) and plant-based Mediterranean-style diet vs. the conventional PPI approach.
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The authors found that compared to the use of H2RA therapy, patients initiated on PPI therapy had a 25% increased risk of death (hazard ratio [HR] 1.25, 95% CI: 1.23-1.28).
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The data indicated continuous PPI use was tied to a reduced risk of cognitive function decline vs. never use (hazard ratio [HR] 0.78, 95% CI: 0.66-0.93; P=0.005).
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In patients with Barrett's esophagus, use of proton pump inhibitors (PPIs) did not lead to dysplasia- or cancer-protective effects.
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Use of acid suppressing agents during pregnancy may increase the risk of asthma in the offspring, according to a study published in The Journal of Allergy and Clinical Immunology.
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The use of acid suppression medicines was associated with higher rates of Clostridium difficile and Campylobacter positive gastroenteritis in both community and hospital settings, according to a study published in the British Journal of Clinical Pharmacology.
