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Infant PPI Use and Lung Infection Risk: Is There a Link?

The data showed matched odds ratio for current vs past use of PPIs to be 0.88 (95% CI, 0.36 to 2.16) when comparing cases and their controls for community-acquired pneumonia. With regard to lower respiratory tract infections, the matched odds ratio between cases and their controls was 1.13 (95% CI, 0.87 to 1.48).

Diet May Be as Effective as PPIs in Reducing Reflux Symptoms

In this retrospective study, researchers from New York Medical College, Valhalla, NY, compared the efficacy of diet-based treatment consisting of alkaline water (pH >8.0) and plant-based Mediterranean-style diet vs. the conventional PPI approach.

Proton Pump Inhibitor Use May Up Death Risk

The authors found that compared to the use of H2RA therapy, patients initiated on PPI therapy had a 25% increased risk of death (hazard ratio [HR] 1.25, 95% CI: 1.23-1.28).

Do PPIs Increase the Risk of Dementia?

The data indicated continuous PPI use was tied to a reduced risk of cognitive function decline vs. never use (hazard ratio [HR] 0.78, 95% CI: 0.66-0.93; P=0.005).

Do Acid Suppression Drugs Up Bacterial Gastroenteritis Risk?

The use of acid suppression medicines was associated with higher rates of Clostridium difficile and Campylobacter positive gastroenteritis in both community and hospital settings, according to a study published in the British Journal of Clinical Pharmacology.