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Clear management guidelines are needed for AKI during immune checkpoint inhibitor therapy, according to investigators.

Study is the largest to explore this potential safety issue to date.

The most common inappropriate medications included proton pump inhibitors, alpha blockers, and NSAIDs.

Avoiding inappropriate use and overdosing of drugs with nephrotoxic effects is an important strategy to prevent hospital-acquired AKI in children, according to investigators.

Prompt diagnosis of AKI and the ability to rule out immune checkpoint inhibitors as the cause may allow patients to continue with cancer immunotherapy.