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ZYVOX for ORAL SUSP
Bacterial infections
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Drug Name:

ZYVOX for ORAL SUSP Rx

Generic Name and Formulations:
Linezolid 100mg/5mL; pwd for reconstitution; orange flavor; contains phenylalanine.

Company:
Pfizer Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for ZYVOX for ORAL SUSP:

Susceptible vancomycin-resistant E. faecium (VREF) infections, nosocomial and community-acquired pneumonia, complicated skin and skin structure infections (including diabetic foot infections) without osteomyelitis, uncomplicated skin and skin structure infections.

Adult Dose for ZYVOX for ORAL SUSP:

Infuse inj over 30–120 minutes; switch to oral form when appropriate. VREF: 600mg every 12 hrs for 14–28 days. Pneumonia, complicated skin and skin structure: 600mg every 12 hrs for 10–14 days. Uncomplicated skin and skin structure (oral forms only): 12–17yrs: 600mg every 12 hrs; >17yrs: 400mg every 12 hrs; both for 10–14 days. MRSA: 600mg every 12 hrs.

Children's Dose for ZYVOX for ORAL SUSP:

Infuse inj over 30–120 minutes; switch to oral form when appropriate. Neonates <7 days: see literature. 0–11yrs: VREF: 10mg/kg every 8 hrs for 14–28 days; pneumonia, complicated skin and skin structure: 10mg/kg every 8 hrs for 10–14 days. Uncomplicated skin and skin structure (oral forms only): <5yrs: 10mg/kg every 8 hrs; 5–11yrs: 10mg/kg every 12 hrs; both for 10–14 days.

See Also:

ZYVOX

ZYVOX I.V. INJECTION

Pharmacological Class:

Oxazolidinone.

Contraindications:

Uncontrolled hypertension. Pheochromocytoma. Thyrotoxicosis. Carcinoid syndrome. During or within 2 weeks of MAOIs (eg, phenelzine, isocarboxazid). Concomitant sympathomimetics (eg, pseudoephedrine), vasopressive agents (eg, epinephrine, norepinephrine), dopaminergics (eg, dopamine, dobutamine), SSRIs, trycyclic antidepressants, triptans, meperidine, buspirone.

Warnings/Precautions:

History of seizures. Monitor CBC's weekly (esp. if otherwise at risk). Consider discontinuing if myelosuppression occurs or worsens. Therapy >28 days. Peripheral and optic neuropathy. Monitor visual function if treatment ≥3 months and if new visual symptoms occur. Diabetes; monitor for hypoglycemia, if occurs, reduce dose or discontinue. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Contraindications. Avoid large amounts of dietary tyramine (keep <100mg/meal). May be antagonized by carbamazepine, phenytoin, phenobarbital. Possible serotonin syndrome with serotonergic agents. Caution with myelosuppressants.

Adverse Reactions:

GI upset, headache, insomnia, constipation, rash, dizziness, pruritus, tongue discoloration, taste alteration, myelosuppression (eg, anemia, thrombocytopenia), lactic acidosis, hypoglycemia, blurred vision, convulsion.

How Supplied:

Tabs—20, 100; Susp—150mL; Inj (100mL, 200mL, 300mL)—1