ZYLOPRIM Rx

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ZYLOPRIM

Gout
Hyperuricemia
Miscellaneous urogenital disorders
Only 4 drugs may be compared at once

Generic Name and Formulations:

Allopurinol 100mg, 300mg; scored tabs.

Select therapeutic use:

Indications for ZYLOPRIM:

Gout.

Adult:

Take with food. Initially 100mg daily. Maintain prophylactic therapy initially. Increase by 100mg daily increments at weekly intervals; max 800mg/day and 300mg/dose. Usual range: mild: 200–300mg daily; severe: 400–600mg daily.

Children:

Not recommended.

Warnings/Precautions:

Discontinue immediately if rash occurs. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides.

Pharmacological Class:

Xanthine oxidase inhibitor.

Adverse Reactions:

Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, Stevens-Johnson syndrome), renal failure.

How Supplied:

100mg—100; 300mg—100, 500

ZYLOPRIM 300mg tablets (Qty:30)

appx. price $138.00

Indications for ZYLOPRIM:

Hyperuricosuria and hyperuricemia induced nephropathy due to cancer chemotherapy.

Adult:

600–800mg daily for 2–3 days with fluids.

Children:

Not recommended.

Warnings/Precautions:

Discontinue immediately if rash occurs. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides.

Pharmacological Class:

Xanthine oxidase inhibitor.

Adverse Reactions:

Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, Stevens-Johnson syndrome), renal failure.

How Supplied:

100mg—100; 300mg—100, 500

ZYLOPRIM 300mg tablets (Qty:30)

appx. price $138.00

Indications for ZYLOPRIM:

Management of recurrent calcium oxalate calculi in hyperuricosurics. Hyperuricosuria and hyperuricemia induced nephropathy due to cancer chemotherapy.

Adult:

Take with food. Calculi: 200–300mg daily. Adjust based on urinary urate levels. Chemotherapy-induced nephropathy prophylaxis: 600–800mg daily for 2–3 days with fluids.

Children:

Usually not recommended. Chemotherapy–induced nephropathy prophylaxis: <6yrs: 150mg daily. 6–10yrs: 300mg daily.

Warnings/Precautions:

Discontinue if rash occurs. Use only if daily uric acid excretion exceeds 800mg in males or 750mg in females. Advise reduction of animal protein, sodium, refined sugars, oxalate-rich foods, and excessive calcium intake. Increase fiber intake. Renal or hepatic dysfunction. Monitor blood, renal, and hepatic tests for first few months of therapy. Maintain neutral or alkaline urine and increase urine output to ≥2 liters daily. Pregnancy (Cat.C). Nursing mothers.

Interactions:

Increase in azathioprine and mercaptopurine toxicity. May potentiate oral anticoagulants, chlorpropamide, cyclosporine. Uricosurics reduce drug effect. Increased rash with ampicillin, amoxicillin. Monitor renal function with thiazides.

Pharmacological Class:

Xanthine oxidase inhibitor.

Adverse Reactions:

Rash, GI disorders, acute gout, ecchymosis, fever, headache, hepatic necrosis, drowsiness, neuritis, arthralgia, necrotizing angiitis, blood dyscrasias, bone marrow depression, toxic skin reactions (eg, Stevens-Johnson syndrome), renal failure.

How Supplied:

100mg—100; 300mg—100, 500

ZYLOPRIM 300mg tablets (Qty:30)

appx. price $138.00