ZOMETA
Generic Name for ZOMETA
Zoledronic acid 4 mg/vial; conc soln for IV infusion after dilution.
Legal Classification:
Rx
Pharmacological Class for ZOMETA
Bisphosphonate.
Manufacturer of ZOMETA
Novartis Pharmaceuticals Corp
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Indications for ZOMETA
Hypercalcemia of malignancy. Adjunct in multiple myeloma and bone metastases of solid tumors.
Adult dose for ZOMETA
Give by IV infusion over at least 15 minutes. Hypercalcemia of malignancy (albumin-corrected serum calcium ≥12 mg/dL): max 4 mg; allow at least 7 days before retreating. Multiple myeloma or bone metastases: CrCl >60mL/min: 4 mg; CrCl 50–60mL/min: 3.5mg; CrCl 40–49mL/min: 3.3mg; CrCl 30–39mL/min: 3mg; CrCl <30mL/min: see literature; all: every 3–4 weeks (give oral multivitamin supplement with calcium 500 mg + Vit. D 400 IU daily).
Children's dosing for ZOMETA
Not recommended.
Contraindications for ZOMETA
Pregnancy (Cat.D).
Warnings/Precautions for ZOMETA
Not recommended for use in patients with with bone metastases and severe renal impairment. Renal or hepatic insufficiency. Check serum creatinine before each dose: withhold until serum creatinine is within 10% of baseline if serum creatinine increases by 0.5 mg/dL from a normal pre-treatment level, or by 1 mg/dL from an abnormal pre-treatment level, within 2 weeks of next dose. Assure adequate hydration when treating hypercalcemia of malignancy. Closely monitor electrolytes (esp. calcium, magnesium, phosphate), CBC/differential, hematocrit, hemoglobin. Aspirin-sensitive asthma. Avoid dental surgery (do preventative dental work before therapy). Elderly. Nursing mothers: not recommended.
Interactions for ZOMETA
Additive hypocalcemic effect with aminoglycosides, loop diuretics. Caution with other nephrotoxic drugs (eg, thalidomide).
Adverse Reactions for ZOMETA
Fever, flu-like syndrome, GI upset, anemia, dyspnea, electrolyte disturbances, musculoskeletal pain (may be severe), hypotension, CNS effects, rigors, headache, paresthesia, renal toxicity; rare: jaw osteonecrosis.
How is ZOMETA supplied?
Vials—1
Related Disease:
Bone metastases
Hypercalcemia
Multiple myeloma
Neoplasms