ADD THIS DRUG TO MY LIST

Select the drug indication to add to your list

ZOMETA
Cytoprotective and supportive care agents
Leukemias, lymphomas, and other hematologic cancers
Compare To Related Drugs
View/Edit/Compare Drugs In My List

Only 4 drugs may be compared at once

Drug Name:

ZOMETA Rx

Generic Name and Formulations:
Zoledronic acid 4mg/5mL concentrated soln for IV infusion after dilution; 4mg/100mL ready-to-use soln for IV infusion.

Company:
Novartis Pharmaceuticals Corp



Therapeutic Use:

Indications for ZOMETA:

Hypercalcemia of malignancy. Limitation of use: not established for use in hyperparathyroidism or nontumor-related hypercalcemia.

Adult Dose for ZOMETA:

Give by IV infusion over at least 15 minutes. Albumin-corrected serum calcium ≥12mg/dL: max 4mg; allow at least 7 days before retreating.

Children's Dose for ZOMETA:

Not recommended.

Pharmacological Class:

Bisphosphonate.

Warnings/Precautions:

Not recommended for use in patients with bone metastases with severe renal impairment. Renal or hepatic insufficiency. Check serum creatinine before each dose: withhold until serum creatinine is within 10% of baseline if serum creatinine increases by 0.5 mg/dL from a normal pre-treatment level, or by 1 mg/dL from an abnormal pre-treatment level, within 2 weeks of next dose. Assure adequate hydration when treating hypercalcemia of malignancy. Correct hypocalcemia before initiating treatment; supplement with calcium and vitamin D. Closely monitor electrolytes (esp. calcium, magnesium, phosphate), CBC/differential, hematocrit, hemoglobin. Evaluate if thigh or groin pain develops and consider discontinuing if atypical femur fracture is suspected. Aspirin-sensitive asthma. Avoid dental surgery (do preventative dental work before therapy). Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Avoid concomitant other bisphosphonates. Additive hypocalcemic effect with aminoglycosides, loop diuretics. Caution with other nephrotoxic drugs (eg, thalidomide).

Adverse Reactions:

Nausea, fatigue, anemia, musculoskeletal pain (discontinue if severe), constipation, fever, vomiting, dyspnea, flu-like syndrome, electrolyte disturbances, hypotension, CNS effects, rigors, headache, paresthesia, renal toxicity; jaw osteonecrosis, atypical subtrochanteric, diaphyseal femoral fractures, severe hypocalcemia.

Elimination:

Renal.

Generic Availability:

NO

How Supplied:

Single-use vial, ready-to-use bottle—1

ZOMETA

  • 5ml of 4mg/5ml vials (Qty:1)
  • appx. price $926.00
GoodRx

Indications for ZOMETA:

Adjunct in multiple myeloma and bone metastases of solid tumors. Limitation of use: not established for use in hyperparathyroidism or nontumor-related hypercalcemia.

Adult Dose for ZOMETA:

Give by IV infusion over at least 15 minutes. CrCl >60mL/min: 4mg; CrCl 50–60mL/min: 3.5mg; CrCl 40–49mL/min: 3.3mg; CrCl 30–39mL/min: 3mg; CrCl <30mL/min: see full labeling; all: every 3–4 weeks (give oral multivitamin supplement with calcium 500mg + Vit. D 400 IU daily).

Children's Dose for ZOMETA:

Not recommended.

Pharmacological Class:

Bisphosphonate.

Warnings/Precautions:

Not recommended for use in patients with bone metastases with severe renal impairment. Renal or hepatic insufficiency. Check serum creatinine before each dose: withhold until serum creatinine is within 10% of baseline if serum creatinine increases by 0.5 mg/dL from a normal pre-treatment level, or by 1 mg/dL from an abnormal pre-treatment level, within 2 weeks of next dose. Assure adequate hydration when treating hypercalcemia of malignancy. Correct hypocalcemia before initiating treatment; supplement with calcium and vitamin D. Closely monitor electrolytes (esp. calcium, magnesium, phosphate), CBC/differential, hematocrit, hemoglobin. Evaluate if thigh or groin pain develops and consider discontinuing if atypical femur fracture is suspected. Aspirin-sensitive asthma. Avoid dental surgery (do preventative dental work before therapy). Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Avoid concomitant other bisphosphonates. Additive hypocalcemic effect with aminoglycosides, loop diuretics. Caution with other nephrotoxic drugs (eg, thalidomide).

Adverse Reactions:

Nausea, fatigue, anemia, musculoskeletal pain (discontinue if severe), constipation, fever, vomiting, dyspnea, flu-like syndrome, electrolyte disturbances, hypotension, CNS effects, rigors, headache, paresthesia, renal toxicity; jaw osteonecrosis, atypical subtrochanteric, diaphyseal femoral fractures, severe hypocalcemia.

Elimination:

Renal.

Generic Availability:

NO

How Supplied:

Single-use vial, ready-to-use bottle—1

ZOMETA

  • 5ml of 4mg/5ml vials (Qty:1)
  • appx. price $926.00
GoodRx

Sign Up for Free e-newsletters