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ZELAPAR
Parkinsonism
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Drug Name:

ZELAPAR Rx

Generic Name and Formulations:
Selegiline 1.25mg; orally-disintegrating tabs; contains phenylalanine.

Company:
Valeant Pharmaceuticals, Inc

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for ZELAPAR:

Adjunct in Parkinson's disease in patients with deteriorating response to levodopa/carbidopa.

Adult Dose for ZELAPAR:

Take (without liquids) in the AM before breakfast; do not eat/drink within 5 minutes (before or after). Place tablet on tongue, do not swallow. ≥16 yrs: 1.25mg once daily for at least 6 weeks; if needed, may increase to max 2.5mg once daily if tolerated. Do not exceed max dose. Not bioequivalent to other forms of selegiline.

Children's Dose for ZELAPAR:

<16yrs: not recommended.

Pharmacological Class:

MAO-B inhibitor.

Contraindications:

During or within 2 weeks of meperidine, MAOIs (eg, other forms of selegiline). Concomitant tramadol, methadone, propoxyphene, dextromethorphan.

Warnings/Precautions:

Renal or hepatic impairment. Monitor for melanoma. Elderly (higher risk of orthostatic hypotension). Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See Contraindications. Avoid sympathomimetic amines, tricyclics, SSRIs, SNRIs; allow at least 14 days after discontinuing selegiline before starting an SSRI (eg, fluoxetine), tricyclic or SNRI; allow 5 weeks after discontinuing fluoxetine before starting selegiline. Caution with CYP3A4 inducers (eg, phenobarbital, phenytoin, carbamazepine, nafcillin, rifampin). Consider reducing concomitant levodopa/carbidopa dose if dyskinesia occurs.

Adverse Reactions:

Postural hypotension (usually transient), dizziness, GI upset, pain, headache, insomnia, rhinitis, stomatitis, hypertension, ECG abnormality, hallucinations.

How Supplied:

Tabs—60

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