Year In Review Schizophrenia
Not only is it difficult to diagnose patients who suffer from both of these disorders, treatment is challenging due to the controversial evidence regarding appropriate therapy.
Periods of relapse often lead to detrimental effects for patients as well as caregivers, therefore it is important to prevent relapse and increase remission time as much as possible.
Sunovion announced the publication of data from a randomized, double-blind, placebo-controlled study that evaluated the efficacy of low-dose Latuda (lurasidone HCl) 20mg daily in adults with schizophrenia, and the effect of dose escalation in adults who demonstrated inadequate initial response to standard dose Latuda.
Researchers investigated the efficacy of individual antidepressants in the treatment of depressive and negative symptoms associated with schizophrenia.
An analysis published in International Clinical Psychopharmacology found that paliperidone palmitate once-monthly (PP1M) had a more favorable benefit-risk profile compared to oral paliperidone extended-release (ER) in the maintenance treatment of schizophrenia through Week 40.
Co-treatment with topiramate and an antipsychotic significantly decreased total, positive, negative, and general psychopathology and weight/body mass index (BMI) in patients with schizophrenia spectrum disorder while being well tolerated, a meta-analysis in the Journal of Clinical Psychology reported.
Antipsychotic-induced somnolence should be managed with sleep hygiene education, selecting an antipsychotic with a lower risk of somnolence, and initiating at a lower dose with a slower titration based on psychiatric diagnoses, a review published in CNS Drugs stated.
Adding vitamin D may lessen the risk of developing new-onset diabetes in patients taking atypical antipsychotics, according to a study published in Scientific Reports.
The approval was based on the results of the REPRIEVE (Relapse prevention study in patients with schizophrenia) clinical study.
In the most definitive study to date, cigarette smoking during pregnancy was linked to a greater likelihood of schizophrenia in offspring. Those are the findings of a new long-term study which assessed maternal nicotine exposure (via cotinine levels) during pregnancy.
Patients taking antipsychotic agents may be at an increased risk of myocardial infarction, based on a review of nine observational studies.
A recent article by Brown and Roffman reviews emerging targets and adjunctive agents under investigation, which may target the negative symptoms and cognitive impairment associated with schizophrenia.
A growing body of evidence suggests that progressive changes in brain structure and function occur with the unfolding of schizophrenia.
Vraylar (cariprazine; Allergan) is now available for the acute treatment of manic or mixed episodes associated with bipolar 1 disorder and for the treatment of schizophrenia in adults.
Patients treated with the antipsychotic clozapine were found to have delayed colonic transit that was 4 times longer than normal, findings from a new study published in EBioMedicine reported.
Antipsychotic (AP) polypharmacy is common in psychiatric practice, despite concerns about its risks and questions regarding its effectiveness.
Nonelderly adults with schizophrenia are 3.5 times more likely to die than adults in the general population. Each individual, on average, loses 28.5 years of life.