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XGEVA
Cytoprotective and supportive care agents
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Drug Name:

XGEVA Rx

Generic Name and Formulations:
Denosumab 120mg/vial (70mg/mL); soln for SC inj; preservative-free.

Company:
Amgen, Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

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Indications for XGEVA:

Prevention of skeletal-related events (SRE) in patients with bone metastases from solid tumors. Not for preventing SRE with multiple myeloma.

Adult Dose for XGEVA:

Give by SC inj into upper arm, upper thigh, or abdomen. 120mg once every 4 weeks.

Children's Dose for XGEVA:

Not established (interferes with bone growth and dentition).

Pharmacological Class:

Osteoclast inhibitor (RANKL inhibitor).

Warnings/Precautions:

Correct hypocalcemia before starting; ensure adequate daily calcium, magnesium, and Vit.D intake, esp. in renal impairment (CrCl<30mL/min). Monitor calcium, phosphorus, magnesium levels in susceptible patients (eg, severe renal impairment, receiving dialysis). Monitor for osteonecrosis of the jaw. Perform oral exam and preventive dentistry before and regularly during therapy. Maintain good oral hygiene. Avoid invasive dental procedures during treatment. Pregnancy (Cat.D; avoid). Nursing mothers: avoid (may impair mammary gland development/lactation).

Interactions:

Concomitant drugs that can lower calcium levels; monitor.

Adverse Reactions:

Fatigue, asthenia, hypophosphatemia, nausea, dyspnea, osteonecrosis of jaw, severe hypocalcemia (may be fatal).

Generic Availability:

NO

How Supplied:

Single-use vial (1.7mL)—1