WELLBUTRIN
Generic Name for WELLBUTRIN
Bupropion HCl 75mg, 100mg; immediate-rel tabs.
Legal Classification:
Rx
Pharmacological Class for WELLBUTRIN
Aminoketone.
Manufacturer of WELLBUTRIN
GlaxoSmithKline Pharmaceuticals
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Indications for WELLBUTRIN
Depression.
Adult dose for WELLBUTRIN
Avoid bedtime dosing. ≥18yrs: initially 100mg twice daily for at least 3 days; if tolerated, increase to 100mg 3 times daily at least 6 hrs apart; max increase 100mg/day per 3-day period. May increase after several weeks to max 450mg/day in 3 divided doses; max single dose: 150mg (give 400mg/day as 100mg 4 times daily at least 4 hrs apart). Severe hepatic cirrhosis: max 75mg once daily. Mild-moderate hepatic cirrhosis, or renal impairment: consider reduced dose and/or dose frequency.
Children's dosing for WELLBUTRIN
<18yrs: not recommended.
Also:
Contraindications for WELLBUTRIN
Seizure disorders. Bulimia. Anorexia nervosa. Within 14 days of MAOIs. Abrupt withdrawal of sedatives or alcohol. Other forms of bupropion (eg, Zyban).
Warnings/Precautions for WELLBUTRIN
History or risk of seizures; discontinue if seizure occurs: do not restart. Hepatic or renal impairment (monitor closely). Depression: clinical worsening or suicidal risk (monitor). Bipolar disorder. Psychosis. Unstable heart disease. CHF. Recent MI. Maintain at lowest effective dose. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for WELLBUTRIN
See Contraindications. Avoid alcohol. Levodopa, amantadine may increase toxicity. Caution with drugs that lower seizure threshold (eg, quinolones, theophylline, antidiabetics, anorectics, CNS stimulants, systemic steroids, antidepressants, antipsychotics) or factors that lower seizure threshold (eg, opiate or cocaine addiction, excessive use of alcohol or sedatives). Caution with drugs metabolized by CYP2B6 (eg, orphenadrine, cyclophosphamide) or CYP2D6 including tricyclic antidepressants, SSRIs (eg, paroxetine, fluoxetine, sertraline), antipsychotics (eg, haloperidol, risperidone, thioridazine), β-blockers (eg, metoprolol), Class 1C antiarrhythmics (eg, propafenone, flecainide); consider dose reduction. May be affected by metabolic enzyme inducers (eg, carbamazepine, phenobarbital, phenytoin), or inhibitors (eg, cimetidine). Monitor for hypertension with nicotine replacement.
Adverse Reactions for WELLBUTRIN
CNS stimulation (eg, agitation, insomnia, seizures, tremor, dizziness), mania/hypomania, psychosis, weight change, dry mouth, headache, migraine, GI effects, edema, rash (rarely may be serious, eg, erythema multiforme, Stevens-Johnson syndrome), palpitations, urinary frequency, sweating, tinnitus, myalgia, hypertension.
How is WELLBUTRIN supplied?
XL tabs—30, 90
SR tabs—60
Immediate-rel tabs—100
Related Disease:
Depression