WELLBUTRIN XL
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WELLBUTRIN XL to:
Generic Name for WELLBUTRIN XL
Bupropion HCl 150mg, 300mg; ext-rel tabs.
Legal Classification:
Rx
Pharmacological Class for WELLBUTRIN XL
Aminoketone.
Manufacturer of WELLBUTRIN XL
GlaxoSmithKline Pharmaceuticals
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Indications for WELLBUTRIN XL
Depression. Seasonal affective disorder.
Adult dose for WELLBUTRIN XL
Swallow whole. Avoid bedtime dosing. ≥18yrs: Depression: initially 150mg once daily in the AM for at least 3 days; if tolerated, increase to 300mg once daily at least 24 hrs apart. May increase after several weeks to max 450mg once daily. Seasonal affective disorder: start in autumn, taper and stop in early spring. 150mg once daily in AM; if tolerated, increase to 300mg once daily after 1 week. Max 300mg/day. Severe hepatic cirrhosis: max 150mg every other day. Mild-moderate hepatic cirrhosis, or renal impairment: consider reduced dose and/or dose frequency.
Children's dosing for WELLBUTRIN XL
<18yrs: not recommended.
Also:
Contraindications for WELLBUTRIN XL
Seizure disorders. Bulimia. Anorexia nervosa. Within 14 days of MAOIs. Abrupt withdrawal of sedatives or alcohol. Other forms of bupropion (eg, Zyban).
Precautions for WELLBUTRIN XL
History or risk of seizures; discontinue if seizure occurs: do not restart. Hepatic or renal impairment (monitor closely). Depression: clinical worsening or suicidal risk (monitor). Bipolar disorder. Psychosis. Unstable heart disease. CHF. Recent MI. Maintain at lowest effective dose. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for WELLBUTRIN XL
See Contraindications. Avoid alcohol. Levodopa, amantadine may increase toxicity. Caution with drugs that lower seizure threshold (eg, quinolones, theophylline, antidiabetics, anorectics, CNS stimulants, systemic steroids, antidepressants, antipsychotics) or factors that lower seizure threshold (eg, opiate or cocaine addiction, excessive use of alcohol or sedatives). Caution with drugs metabolized by CYP2B6 (eg, orphenadrine, cyclophosphamide) or CYP2D6 including tricyclic antidepressants, SSRIs (eg, paroxetine, fluoxetine, sertraline), antipsychotics (eg, haloperidol, risperidone, thioridazine), β-blockers (eg, metoprolol), Class 1C antiarrhythmics (eg, propafenone, flecainide); consider dose reduction. May be affected by metabolic enzyme inducers (eg, carbamazepine, phenobarbital, phenytoin), or inhibitors (eg, cimetidine). Monitor for hypertension with nicotine replacement.
Adverse Reactions for WELLBUTRIN XL
CNS stimulation (eg, agitation, insomnia, seizures, tremor, dizziness), mania/hypomania, psychosis, weight change, dry mouth, headache, migraine, GI effects, edema, rash (rarely may be serious, eg, erythema multiforme, Stevens-Johnson syndrome), palpitations, urinary frequency, sweating, tinnitus, myalgia, hypertension.
How is WELLBUTRIN XL supplied?
XL tabs—30, 90
SR tabs—60
Immediate-rel tabs—100
Related Disease:
Depression