WELLBUTRIN SR
Compare
WELLBUTRIN SR to:
Generic Name for WELLBUTRIN SR
Bupropion HCl 100mg, 150mg, 200mg; sust-rel tabs.
Legal Classification:
Rx
Pharmacological Class for WELLBUTRIN SR
Aminoketone.
Manufacturer of WELLBUTRIN SR
GlaxoSmithKline Pharmaceuticals
|
Indications for WELLBUTRIN SR
Depression.
Adult dose for WELLBUTRIN SR
Swallow whole. Avoid bedtime dosing. ≥18yrs: initially 150mg once daily in the AM for at least 3 days; if tolerated, increase to 150mg twice daily at least 8 hrs apart. May increase after several weeks to max 200mg twice daily at least 8 hrs apart. Severe hepatic cirrhosis: max 100mg/day or 150mg every other day. Mild-moderate hepatic cirrhosis, or renal impairment: consider reduced dose and/or dose frequency.
Children's dosing for WELLBUTRIN SR
<18yrs: not recommended.
Also:
Contraindications for WELLBUTRIN SR
Seizure disorders. Bulimia. Anorexia nervosa. Within 14 days of MAOIs. Abrupt withdrawal of sedatives or alcohol. Other forms of bupropion (eg, Zyban).
Precautions for WELLBUTRIN SR
History or risk of seizures; discontinue if seizure occurs: do not restart. Hepatic or renal impairment (monitor closely). Depression: clinical worsening or suicidal risk (monitor). Bipolar disorder. Psychosis. Unstable heart disease. CHF. Recent MI. Maintain at lowest effective dose. Write ℞ for smallest practical amount. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for WELLBUTRIN SR
See Contraindications. Avoid alcohol. Levodopa, amantadine may increase toxicity. Caution with drugs that lower seizure threshold (eg, quinolones, theophylline, antidiabetics, anorectics, CNS stimulants, systemic steroids, antidepressants, antipsychotics) or factors that lower seizure threshold (eg, opiate or cocaine addiction, excessive use of alcohol or sedatives). Caution with drugs metabolized by CYP2B6 (eg, orphenadrine, cyclophosphamide) or CYP2D6 including tricyclic antidepressants, SSRIs (eg, paroxetine, fluoxetine, sertraline), antipsychotics (eg, haloperidol, risperidone, thioridazine), β-blockers (eg, metoprolol), Class 1C antiarrhythmics (eg, propafenone, flecainide); consider dose reduction. May be affected by metabolic enzyme inducers (eg, carbamazepine, phenobarbital, phenytoin), or inhibitors (eg, cimetidine). Monitor for hypertension with nicotine replacement.
Adverse Reactions for WELLBUTRIN SR
CNS stimulation (eg, agitation, insomnia, seizures, tremor, dizziness), mania/hypomania, psychosis, weight change, dry mouth, headache, migraine, GI effects, edema, rash (rarely may be serious, eg, erythema multiforme, Stevens-Johnson syndrome), palpitations, urinary frequency, sweating, tinnitus, myalgia, hypertension.
How is WELLBUTRIN SR supplied?
XL tabs—30, 90
SR tabs—60
Immediate-rel tabs—100
Related Disease:
Depression