Generic Name and Formulations:
Colesevelam HCl 1.875g, 3.75g; pwd pkts; citrus flavored; contains phenylalanine 24mg/1.875g pkt; 48mg/3.75g pkt.
Company:
Daiichi Sankyo
Adjunct to diet and exercise in type 2 diabetes in combination with metformin, sulfonylureas, or insulin.
Take with a meal and liquid. 3 tabs twice daily or 6 tabs once daily. Susp: one 1.875g pkt twice daily or one 3.75g pkt once daily. Empty contents into a glass or cup, add 4–8oz of water, fruit juice, or diet soft drinks; stir and drink. Do not take susp in its dry form.
Not recommended.
Bile acid sequestrant.
History of bowel obstruction. Serum TG>500mg/dL. History of hypertriglyceridemia-induced pancreatitis.
Not for treating type 1 diabetes or diabetic ketoacidosis. TG levels >300mg/dL. Monitor lipids, TG, and non-HDL-C levels prior to therapy and periodically thereafter. Susceptibility to Vit. A, D, E, or K deficiencies. Risk of bowel obstruction (eg, gastroparesis, other GI motility disorders, or a history of major GI surgery). Dysphagia or swallowing disorders (esp. w/tab form). Pregnancy (Cat.B). Nursing mothers.
Monitor drugs with a narrow therapeutic index, glyburide, levothyroxine, oral contraceptives containing ethinyl estradiol and norethindrone, phenytoin, warfarin; give at least 4 hours prior to colesevelam. May potentiate metformin extended-release.
Constipation, dyspepsia, nausea, dysphagia.
Renal.
NO
Tabs—180; Susp 1.875g—60 (single-dose pkt); 3.75g—30 (single-dose pkt)
Adjunct to diet and exercise: to reduce elevated LDL-C in adults with primary hypercholesterolemia (Type IIa), alone or with a statin, when response to nondrug therapy is inadequate; to reduce LDL-C in boys and postmenarchal girls 10–17yrs of age with heterozygous familial hypercholesterolemia, alone or with a statin after failing an adequate trial of diet therapy.
<10yrs: not recommended. Take with a meal and liquid. ≥10yrs: Susp: one 1.875g pkt twice daily or one 3.75g pkt once daily. Empty contents into a glass or cup, add 4–8oz of water, fruit juice, or diet soft drinks; stir and drink. Do not take susp in its dry form. >17yrs: 3 tabs twice daily or 6 tabs once daily. With a statin: may be dosed at the same time or dosed apart.
Bile acid sequestrant.
History of bowel obstruction. Serum TG>500mg/dL. History of hypertriglyceridemia-induced pancreatitis.
TG levels >300mg/dL. Monitor lipids, TG, and non-HDL-C levels prior to therapy and periodically thereafter. Susceptibility to Vit. A, D, E, or K deficiencies. Risk of bowel obstruction (eg, gastroparesis, other GI motility disorders, or a history of major GI surgery). Dysphagia or swallowing disorders (esp. w/tab form). Pregnancy (Cat.B). Nursing mothers.
Monitor drugs with a narrow therapeutic index, glyburide, levothyroxine, oral contraceptives containing ethinyl estradiol and norethindrone, phenytoin, warfarin; give at least 4 hours prior to colesevelam. May potentiate metformin extended-release.
Constipation, dyspepsia, nausea, dysphagia.
Renal.
NO
Tabs—180; Susp 1.875g—60 (single-dose pkt); 3.75g—30 (single-dose pkt)