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VYVANSE
ADHD
Anxiety/OCD
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Drug Name:

VYVANSE CII

Generic Name and Formulations:
Lisdexamfetamine dimesylate 10mg, 20mg, 30mg, 40mg, 50mg, 60mg, 70mg; caps.

Company:
Shire US, Inc.

Therapeutic Use:

Indications for VYVANSE:

Attention deficit hyperactivity disorder.

Adults and Children:

<6yrs: not established. Swallow whole or may open and mix/dissolve contents of capsule in yogurt, water, orange juice; take immediately (do not subdivide caps). Individualize. ≥6yrs: initially 30mg once daily in AM. May adjust in increments of 10mg or 20mg at weekly intervals; max 70mg/day. Severe renal impairment (GFR 15–<30mL/min/1.73m2): max 50mg/day; ESRD (GFR <15mL/min/1.73m2): max 30mg/day.

Contraindications:

During or within 14 days of MAOIs.

Warnings/Precautions:

Risk of potential abuse and dependence; monitor. Increased risk of sudden death, stroke, and MI. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, and other cardiac problems. Bipolar disorder. Screen for risk factors in developing manic episode prior to initiating. Psychosis. Risk of peripheral vasculopathy, including Raynaud's phenomenon; monitor for digital changes. Monitor growth (esp. children), BP, HR. Write ℞ for smallest practical amount. Reevaluate periodically. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See Contraindications. Hypertensive crisis with MAOIs. Potentiated by sodium bicarbonate and other urinary alkalinizing agents. Antagonized by urinary acidifiers (eg, ascorbic acid).

Pharmacological Class:

CNS stimulant.

Adverse Reactions:

Anorexia, anxiety, decreased appetite/weight, diarrhea, dizziness, dry mouth, irritability, insomnia, nausea, upper abdominal pain, vomiting; hypertension, tachycardia, rash (may be serious).

How Supplied:

Caps—100

Indications for VYVANSE:

Moderate-to-severe binge eating disorder.

Limitations Of use:

Not indicated for weight loss. Safety and effectiveness not established for treating obesity.

Adult:

Swallow whole or may open and mix/dissolve contents of capsule in yogurt, water, orange juice; take immediately (do not subdivide caps). Individualize. ≥18yrs: initially 30mg once daily in the AM. May adjust in increments of 20mg at weekly intervals to target dose of 50–70mg/day; max 70mg/day. Discontinue if binge eating does not improve. Severe renal impairment (GFR 15–<30mL/min/1.73m2): max 50mg/day; ESRD (GFR <15mL/min/1.73m2): max 30mg/day.

Children:

<18yrs: not established.

Contraindications:

During or within 14 days of MAOIs.

Warnings/Precautions:

Risk of potential abuse and dependence; monitor. Increased risk of sudden death, stroke, and MI. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, and other cardiac problems. Bipolar disorder. Screen for risk factors in developing manic episode prior to initiating. Psychosis. Risk of peripheral vasculopathy, including Raynaud's phenomenon; monitor for digital changes. Monitor growth (esp. children), BP, HR. Write ℞ for smallest practical amount. Reevaluate periodically. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See Contraindications. Hypertensive crisis with MAOIs. Potentiated by sodium bicarbonate and other urinary alkalinizing agents. Antagonized by urinary acidifiers (eg, ascorbic acid).

Pharmacological Class:

CNS stimulant.

Adverse Reactions:

Anorexia, anxiety, decreased appetite/weight, diarrhea, dizziness, dry mouth, irritability, insomnia, nausea, upper abdominal pain, vomiting; hypertension, tachycardia, rash (may be serious).

How Supplied:

Caps—100

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