Viral Infections

Multilevel Interventions Needed to Improve Barriers to PrEP

By June 13, 2018

The final review included 47 articles that fell under 1 of the following categories: primary data on cognitive variables of providers; data on cognitive variables and perspectives of individuals at risk for HIV infection; literature on PrEP implementation; and case studies of PrEP demonstration and implementation projects.

HPV Vaccine Under Priority Review for Expanded Age Range

By June 13, 2018

Specifically, the types the vaccine protects against are HPV 16, 18, 31, 33, 45, 52, 58 (which cause ~90% of cervical cancer cases worldwide), and types 6 and 11 which case genital warts.

Active Failures Seen in Proper Use of Personal Protective Equipment

June 12, 2018

Violations included entering rooms without some or all recommended PPE; during PPE removal, mistakes were frequently observed, as well as during encounters with challenging logistical situations, such as badge-enforced computer logins.

Lengthy Viral Suppression May Cut Cancer Risk in HIV Infected

June 12, 2018

The researchers found that cancer incidence for HIV-positive vs uninfected persons was highest for unsuppressed persons (relative risk [RR], 2.35), lower among persons with early suppression (RR, 1.99), and lowest among persons with long-term suppression (RR, 1.52).

CDC Issues Updated Advisory Regarding Outbreaks of Hepatitis A

By June 11, 2018

Of the 2500 cases of hepatitis A infection reported between January 2017 and April 2018, 68% were among persons who reported drug use (injection and non-injection), homelessness, or both.

HIV Pre-Exposure Prophylaxis Linked to Drop in Condom Use

June 07, 2018

Consistent condom use was reported by 46, 42, and 31% of men in 2013, 2016, and 2017, respectively (P<.001).

FDA Grant Orphan Drug Status to Brincidofovir for Smallpox

By June 07, 2018

Brincidofovir is the Company's lead candidate, a nucleotide analog that has antiviral activity against variola virus, which causes smallpox.

Post-Transplant Tx Reduces Wait for Kidney in Hep C&#43; Patients

June 07, 2018

In the post-transplant group, the median waitlist time was 122 days, which was significantly shorter than the center's regional and national wait time. There was no difference in allograft quality based on pathologic review or treatment-related adverse events between the two groups.

Prezcobix Not Recommended During Pregnancy, According to Updated Labeling

By June 05, 2018

The labeling now states that Prezcobix is not recommended for use in pregnant women due to substantially lower exposures of the active ingredients, darunavir and cobicistat, during pregnancy.

CDC: Administration Errors Reported With New Shingles Vaccine

By May 30, 2018

Between October 20, 2017 and February 20, 2018, the Vaccine Adverse Event Reporting System (VAERS) received 155 reports involving RZV, with 13 (8%) involving an administrative error.

Herpes Zoster Vaccination Rates Assessed Among People Living With HIV

By May 28, 2018

The authors found that vaccination rates varied between 1.5% and 42.4% at the 6 institutions assessed and that 21.3% of eligible patients at the University of Colorado received HZV prior to the intervention.

HCV Guidelines Updated to Include Recommendations for Key Populations

By May 25, 2018

The guidelines were developed by the American Association for the Study of Liver Diseases and the Infectious Diseases Society of America.

Two Hepatitis C Virus Infection Treatments to Be Discontinued

By May 24, 2018

The discontinuation is voluntary and is not related to product quality, safety or efficacy.

HPV Vaccination Coverage, Trends by Age Examined in US

By May 24, 2018

Provider-verified vaccination records obtained from a pilot study conducted in 14-29-year-old patients were utilized to determine the sensitivity and specificity of the self/parent-reported vaccination data.

AAP Recommends Shot Over Nasal Spray for 2018-2019 Flu Season

By May 22, 2018

The advisory comes early as physicians are currently placing vaccine orders.

Robust Immune Responses for Herpes Zoster Subunit Vaccine

May 21, 2018

The researchers identified a humoral response in 97.8 and 2% of HZ/su and placebo recipients, respectively, after vaccination.

FDA: Possible Risk of Neural Tube Birth Defects With Certain HIV Meds

By May 18, 2018

The Agency has received reports of serious neural tube birth defects involving the brain, spine, and spinal cord in babies born to women who received dolutegravir for HIV treatment.

Proportion of Drug-Intoxicated Organ Donors on the Rise in US

May 18, 2018

There was no significant difference in survival after transplantation for recipients of organs from donors who died from drug intoxication or blunt head injury; results were similar for comparisons involving other causes of death.

Truvada Approved for HIV-1 Pre-Exposure Prophylaxis in At-Risk Adolescents

By May 17, 2018

The use of Truvada for PrEP in the adolescent population was based on a single-arm, open-label clinical study (ATN113) among 67 HIV-1 negative young men (aged 15 to 17 years) who have sex with men (YMSM).

New Rabies Test Could Radically Change Testing, Treatment

May 17, 2018

LN34 doesn't require complex training. And it can produce reliable results whether the animal tissue probed is fresh, frozen, or decomposed, the researchers said.

Hepatitis C-Exposed Infants Not Adequately Screened

May 16, 2018

HCV-infected women were more likely to be <30 years of age (67 vs 53%), be white (93 vs 72%), be insured by Medicaid (77 vs 29%), and have opiate use disorder (68 vs 1%) compared with HCV-uninfected women.

HPV Vaccination May Offer Protection Against Cervical Precancer

By May 11, 2018

The authors concluded, "There is high-certainty evidence that HPV vaccines protect against cervical precancer in adolescent girls and young women aged 15 to 26," while also indicated that future studies should have long-term follow-up.

Sofosbuvir Improves Renal Safety in Patients With Chronic Hep C

May 11, 2018

In patients with glomerular filtration rate (GFR) ≥45 mL/min/1.73 m² there was significant improvement in renal biomarkers, as indicated by a progressive increase in mean GFR values until 1 year.

Cancer Incidences and Burden Expected to Shift in HIV-Positive

May 08, 2018

The estimated total cancer burden in PLWH will decrease from 8,150 cases in 2010 to 6,690 cases in 2030, with prostate and lung cancer projected to be the most common cancer types.

Eyes of Ebola Survivors Show Localized Pathological Changes

May 07, 2018

All lesions respected the horizontal raphe, and the fovea was spared. A V-shaped hyperreflectivity of the outer nuclear layer was seen with OCT imaging, overlying discontinuities of the ellipsoid zone and interdigitation zone in smaller lesions.

Vaccine for Chikungunya Prevention Gets Fast Track Designation

By May 04, 2018

There are currently no approved treatments or vaccines available for chikungunya, a virus transmitted through mosquito bites.

HBV Reactivation Examined in Patients Treated With TNF Antagonists

By May 03, 2018

The authors examined data from 8887 individuals who began TNF antagonist treatment for an autoimmune disease from 2001 through 2010 and were followed through 2012; 52% of these patients were screened for HBV before treatment.

Screening insufficient for newborns exposed to hepatitis C virus

May 02, 2018

In this retrospective study, only a fraction of infants receiving well-child care at the study institution were screened for hepatitis C, despite being born to mothers with a known history of hepatitis C virus infection.

Vectorborne Diseases Up More Than Two-Fold From 2004 to 2016

May 02, 2018

During 2004 to 2016, 82 percent of all tickborne disease reports were Lyme disease

In-utero exposure to tenofovir-emtricitabine not associated with higher risk of adverse birth outcomes

May 01, 2018

Pairwise comparisons of tenofovir-emtricitabine and ritonavir-boosted lopinavir (TDF-FTC-LPV/r), zidovudine-lamivudine and ritonavir-boosted lopinavir (ZDV-3TC-LPV/r), and tenofovir-emtricitabine and ritonavir-boosted atazanavir (TDF-FTC-ATV/r) HIV regimens among pregnant women with HIV showed all three regimens had comparable risks of preterm birth, low birth weight, and neonatal death.