Viral Infections

CDC: Update on Influenza Activity in the U.S.

December 08, 2017

Influenza activity was low during October 2017, has been increasing since the start of November

Antiretroviral Combination Linked to Increased CKD Risk

By December 08, 2017

The risk of chronic kidney disease (CKD) may be increased in patients living with HIV receiving tenofovir (TDF) with a ritonavir-boosted protease inhibitor compared to those who receive TDF with a non-nucleosidic reverse transcriptase inhibitor (NNRTI)

Newly Approved Prophylaxis Assessed in CMS-Seropositive Transplant Recipients

December 08, 2017

The researchers found that among 495 patients with undetectable CMV DNA at randomization, fewer patients in the letermovir group had clinically significant CMV infection or were classified as having a primary end point event by week 24 after transplantation, compared with the placebo group.

Cancer Drug Linked to Drastic Depletion of HIV Reservoirs

December 04, 2017

Case report describes smoker with HIV infection receiving nivolumab for non-small-cell lung cancer

New Guidelines Issued for Managing Chronic Pain in HIV Patients

By November 30, 2017

All PWLH should receive brief standardized screening for chronic pain. A biopsychosocial approach should be used; and appropriate monitoring should take place.

CDC: 7-Month Improvement in Time From HIV Infection to Diagnosis

November 29, 2017

Increase in percentage of people at increased risk for HIV who reported getting an HIV test in past year.

Can Co-Testing Support Longer Cervical Cancer Screening Intervals?

November 28, 2017

Regardless of the cytology result, 5-year ≥CIN3 risks for an HPV-negative co-test nearly matched the performance of a negative co-test for each successive round of screening (0.114, 0.061, and 0041%, respectively).

Impact of MenACWY Vaccine Program on Disease Incidence Examined

By November 27, 2017

Reductions in incidence suggest an impact of the MenACWY vaccine program in this age group.

First Complete 2-Drug HIV Regimen Gets FDA Approval

By November 21, 2017

Juluca combines dolutegravir, an HIV-1 integrase strand transfer inhibitor (INSTI), and rilpivirine, a non-nucleoside reverse transcriptase inhibitor.

ACP/CDC: Best Practice Advice for Hepatitis B Vaccination, Screening

November 21, 2017

All unvaccinated adults at risk for infection should be vaccinated; screening recommended for at-risk

Antiviral Prescribing for Flu Examined Among High-Risk Patients

By November 20, 2017

The investigators determined that empiric treatment of 4 patients with acute respiratory illness who were considered high-risk was needed to treat 1 with positive influenza laboratory tests.

Early cART, Viral Suppression May Minimize Brain Injury in HIV Patients

November 15, 2017

No significant neuropsychological decline during two-year period with combination antiretroviral therapy

Labeling for Several HCV Drugs Updated With New Drug Interactions

By November 13, 2017

The Food and Drug Administration (FDA) has approved updated labeling for several hepatitis C virus (HCV) infection treatments.

In ART-Treated HIV Patients With GI Discomfort, Consider EPI Assessment

By November 13, 2017

Of 100 participants, 32% had EPI (faecal elastase-1 <200 μg/g) and 20% severe EPI (faecal elastase-1 <100 μg/g).

New Vaccine for Hepatitis B Gets FDA Approval

By November 10, 2017

Two-dose vaccine for the prevention of hepatitis B in adults.

Prevymis Approved for Prevention of Cytomegalovirus Infection and Disease

By November 09, 2017

Prevymis, a non-nucleoside CMV inhibitor (3,4 dihydro-quinazoline), inhibits viral replication through targeting the viral terminase complex.

Previous West Nile Infection Linked to Neurologic Abnormalities

November 09, 2017

Data were included for 262 patients with a history of WNV enrolled in a longitudinal cohort from 2002 to 2012; 117 patients underwent neurologic and neurocognitive evaluations.

Direct-Acting Antivirals Beneficial for HCV/HIV Co-Infected Patients

By November 07, 2017

The authors write, "the advent of direct acting antiviral (DAA) agent therapies has resulted in significant improvements in treatment rates for those with co-infection."

Vaccine for Universal Pneumococcal Disease Prevention in the Works

November 02, 2017

The researchers report that non-covalent colocalization of two classes of complementary antigens, one to prevent the colonization of the most aggressive S. pneumoniae serotypes and another to restrict virulence transition, provides complete vaccine effectiveness.

Four in 10 HCPs Work While Experiencing Flu-Like Illness, Says Survey

By November 01, 2017

The most common reasons for HCPs to opt from taking sick leave included feeling that s/he could still preform his/her job duties; not feeling "bad enough" to stay home.

Novel Monoclonal Antibody Targeting Influenza A Gets Fast Track Status

By November 01, 2017

VIS410, a monoclonal antibody, is being developed for single-dose administration to target all known strains of influenza A.

Influenza Oral Tablet Vaccine Shows Promise in Phase 2 Trial

By October 27, 2017

Results showed that the tablet group had a 39% reduction in clinical disease compared to placebo and a 27% reduction compared to the injectable QIV.

Increasing Resistance to HIV Drugs Threatening Control Efforts

October 26, 2017

WHO has proposed 5-point plan for monitoring, combating, and preventing drug resistance

FDA Approves Shingrix for Prevention of Shingles

By October 23, 2017

The use of Shingrix also decreased the overall incidence of postherpetic neuralgia (PHN).

Further Adaptation of Avian Virus May Lead to Pandemic

October 23, 2017

In vivo, neuraminidase inhibitors showed limited effectiveness against these viruses, but the viruses were susceptible to a polymerase inhibitor.

Renal Testing Recommendations Added to Atazanavir Labeling

By October 20, 2017

Renal lab testing should be performed on all patients prior to initiating treatment and during treatment.

HCV Treatment With DAAs Reduces Liver Cancer Risk Significantly

By October 20, 2017

Study authors from the University of Washington, Seattle, and Veterans Affairs Puget Sound Healthcare System in Seattle sought to investigate whether HCV eradication with DAAs could lower the risk of liver cancer in patients.

CDC Updates Zika Guidance With 3 Clinical Scenarios

October 20, 2017

"Health care providers should remain alert for abnormal findings in infants with possible congenital Zika virus exposure without apparent abnormalities at birth," the authors write.

Aspirin May Aid in Preventing Liver Cancer in Hep B Patients

October 20, 2017

The researchers found that the cumulative incidence of HCC in the treated group was significantly lower than that in the untreated group in five years.

SMFM Issues Recommendations on Managing Hepatitis C in Pregnancy

By October 19, 2017

The recommendations will be published in the November issue of the American Journal of Obstetrics and Gynecology.