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Drug Name:


Generic Name and Formulations:
Vilazodone HCl 10mg, 20mg, 40mg; tabs.

Forest Laboratories

e-Prescribe this drug via Surescripts

Therapeutic Use:

Indications for VIIBRYD:

Major depressive disorder.

Adult Dose for VIIBRYD:

Take with food. Initially 10mg once daily for 7 days, then 20mg once daily for 7 days, then increase to 40mg once daily. Concomitant strong CYP3A4 inhibitors (eg, ketoconazole) or moderate CYP3A4 inhibitors (eg, erythromycin) with intolerable adverse events: reduce to 20mg once daily. Reevaluate periodically.

Children's Dose for VIIBRYD:

Not recommended.

Pharmacological Class:

Selective serotonin reuptake inhibitor + 5-HT1A receptor partial agonist.


Concomitant MAOIs within 14 days of discontinuing vilazodone. Within 14 days of discontinuing MAOIs. Concomitant linezolid or IV methylene blue.


Monitor for clinical worsening, suicidality, or unusual changes in behavior. Activation of mania/hypomania; screen patients for bipolar disorder. Seizure disorder. Severe hepatic impairment. Avoid abrupt cessation. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.


See Contraindications. Increased risk of serotonin syndrome with other serotonergic drugs (eg, triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's Wort) or with drugs that impair serotonin metabolism (eg, MAOIs, linezolid, IV methylene blue). Increased risk of bleeding with concomitant aspirin, NSAIDs, warfarin (monitor), other anticoagulants. Potentiated by CYP3A4 inhibitors. Antagonized by CYP3A4 inducers. Caution with other highly protein bound drugs.

Adverse Reactions:

GI upset, insomnia; hyponatremia (esp. in elderly), possible neuroleptic malignant syndrome (monitor; discontinue if occurs).

How Supplied:

Tabs—30; Patient Starter Kit (7x10mg tabs, 7x20mg tabs, 16x40mg tabs)—30

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