VICTOZA Rx

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VICTOZA

Diabetes
Only 4 drugs may be compared at once

Generic Name and Formulations:

Liraglutide 6mg/mL; soln for SC inj.

Company:

Novo Nordisk

Select therapeutic use:

Indications for VICTOZA:

As adjunct to diet and exercise, to improve glycemic control in adults with type 2 diabetes mellitus (T2DM). To reduce the risk of major adverse CV events (eg, CV death, non-fatal MI/stroke) in adults with T2DM and established CV disease.

Limitations Of use:

Not a substitute for insulin. Not for treating type 1 diabetes or diabetic ketoacidosis. Not studied in combination with prandial insulin.

Adult:

Give by SC inj in abdomen, thigh, or upper arm once daily. Initially 0.6mg/day for 1 week, then 1.2mg/day; may increase to 1.8mg/day. If >3 days elapsed since last dose, reinitiate at 0.6mg/day, then titrate. Renal impairment: caution with initiating or escalating doses.

Children:

<18yrs: not recommended.

Contraindications:

History (personal or family) of medullary thyroid carcinoma. Multiple endocrine neoplasia syndrome type 2.

Warnings/Precautions:

Risk of thyroid C-cell tumors; inform patients of potential risk and symptoms. Discontinue if pancreatitis is suspected; do not restart if confirmed. History of pancreatitis: limited data. Evaluate if cholelithiasis is suspected. Do not reuse or share pens or needles between patients. History of anaphylaxis or angioedema with other GLP-1 receptor agonist. Discontinue if hypersensitivity reactions occur. Renal impairment. Hepatic impairment: use with caution (limited data). Dehydration. Gastroparesis: not studied. Pregnancy. Nursing mothers.

Interactions:

Concomitant insulin; administer as separate injections not adjacent to each other. Hypoglycemia with sulfonylureas or insulin (consider reducing their doses). May affect absorption of concomitant oral drugs (delayed gastric emptying); caution.

Pharmacological Class:

Glucagon-like peptide-1 (GLP-1) receptor agonist.

Adverse Reactions:

Nausea, diarrhea, headache, vomiting, decreased appetite, dyspepsia, constipation, immunogenicity reactions (eg, urticaria); rare: pancreatitis, papillary thyroid carcinoma, hypersensitivity reactions.

Generic Availability:

NO

How Supplied:

Multi-dose, pre-filled pens (3mL)—2, 3

VICTOZA 3 pens of 18mg/3ml cartons (Qty:1)

appx. price $832.00