Generic Name and Formulations:
Doxycycline (as hyclate) 50mg, 100mg; caps.
Company:
Pfizer Inc.
Adjunct in severe acne.
100mg every 12 hrs for 1 day, then 100mg/day in 1–2 divided doses. Reduce dose after improvement. Take with fluid.
Not applicable.
Tetracycline.
Monitor blood, renal, and hepatic function in long-term use. Avoid sun and UV light. Asthma (syrup). Pregnancy (Cat.D), nursing mothers: not recommended.
May increase digoxin levels. Antacids, iron, zinc, calcium, magnesium, urinary alkalinizers reduce absorption. Avoid concomitant penicillins, methoxyflurane. Carbamazepine, hydantoins may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.
Photosensitivity, GI upset, rash, blood dyscrasias, hepatotoxicity.
Formerly known under the brand name Vibra-Tabs.
Caps 50mg—50; 100mg—50, 500; Syrup—1oz, pt; Susp—2oz; Tabs—Contact supplier.
Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma. Postexposure prophylaxis and treatment of anthrax.
Take with fluids. 100mg every 12 hours for 1 day; then 100mg daily; max 200mg daily. Postexposure prophylaxis of inhalational anthrax, or treatment of cutaneous anthrax: 100mg orally every 12 hours (start as soon as possible after exposure). Treatment of inhalational, GI, or oropharyngeal anthrax, or cutaneous anthrax with systemic involvement, extensive edema, or head/neck lesions: use an IV form initially at 100mg IV every 12 hours (w. 1 or 2 other antimicrobials), then switch to oral form at 100mg every 12 hours. Treat for a total of 60 days.
<8 years: usually not recommended. ≥8 years (≤100lbs): 2mg/lb divided in 2 doses for 1 day; then 1–2mg/lb daily in 1–2 doses; max 2mg/lb daily. >100lbs: 100 mg orally every 12 hours. Postexposure prophylaxis of inhalational anthrax, or treatment of cutaneous anthrax: >8 years (>45kg): as adult; >8 years (≤45kg) or ≤8 years: 2.2 mg/kg orally every 12 hours. Treatment of inhalational, GI, or oropharyngeal anthrax, or cutaneous anthrax with systemic involvement, extensive edema, or head/neck lesions: >8 years (>45kg): use an IV form first at 100 mg every 12 hours (w. 1 or 2 other antimicrobials), then switch to oral form at same dose; >8 years (≤45kg) or ≤8 years: 2.2 mg/kg IV every 12 hours (w. 1 or 2 other antimicrobials), then switch to oral form at same dose. Treat for a total of 60 days.
Tetracycline.
Monitor blood, renal, and hepatic function in long-term use. Sunlight or UV light. Asthma (syrup). Pregnancy (Cat.D), nursing mothers: usually not recommended.
May increase digoxin levels. Antacids, iron, zinc, calcium, magnesium, urinary alkalinizers reduce absorption. Avoid concomitant penicillins, methoxyflurane. Carbamazepine, hydantoins may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.
Photosensitivity, GI upset, rash, blood dyscrasias, hepatotoxicity.
See MMWR Vol 50, No.42 (Oct. 26, 2001) for more information on anthrax.
Caps 50mg—50; 100mg—50, 500; Syrup—1oz, pt; Susp—2oz; Tabs—Contact supplier.
Short term prophylaxis of P. falciparum.
100mg daily; begin 1–2 days before, continue during and 4 weeks after travel to malarious area.
Under 8 yrs: not recommended. Over 8 yrs: 2mg/kg daily; max 100mg daily; begin 1–2 days before, continue during and 4 weeks after travel to malarious area.
Tetracycline.
Monitor blood, renal, and hepatic function in long-term use. Avoid sun and UV light. Asthma (syrup). Pregnancy (Cat.D), nursing mothers: not recommended.
May increase digoxin levels. Antacids, iron, zinc, calcium, magnesium, urinary alkalinizers reduce absorption. Avoid concomitant penicillins, methoxyflurane. Carbamazepine, hydantoins may decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.
Photosensitivity, GI upset, rash, blood dyscrasias, hepatotoxicity.
Caps 50mg—50; 100mg—50, 500; Syrup—1oz, pt; Susp—2oz; Tabs—Contact supplier.