VERELAN PM Rx

Indications for VERELAN PM:

Hypertension.

Adult Dose for VERELAN PM:

Give once daily at bedtime. May sprinkle contents on applesauce; do not crush or chew contents. Initially 200mg; may titrate upwards in steps to 300mg, then 400mg if necessary. May start at 100mg in impaired renal or hepatic function, elderly or small patients.

Children's Dose for VERELAN PM:

Not recommended.

See Also:

VERELAN

Pharmacological Class:

Calcium channel blocker (diphenylalkylamine).

Contraindications:

Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2^nd- or 3^rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract.

Warnings/Precautions:

Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates alcohol, α- and β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine. Potentiated by grapefruit juice. Avoid disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium, cyclosporine.

Adverse Reactions:

Hypotension, edema, AV block, bradycardia, CHF, constipation, headache, dizziness, fatigue, dyspepsia, elevated hepatic enzymes, paralytic ileus.

How Supplied:

Caps—100