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Vancomycin Inj
Bacterial infections
Diarrhea
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Drug Name:

Vancomycin Inj Rx

Generic Name and Formulations:
Vancomycin (as HCl) 500mg/vial, 1g/vial; lyophilized pwd for IV infusion after reconstitution and dilution.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Vancomycin Inj:

Serious or severe infections due to susceptible methicillin-resistant (beta-lactam-resistant) staphylococci in penicillin-allergic patients; patients who cannot receive or have failed to respond to other drugs, including penicillins and cephalosporins; and for infections due to vancomycin-susceptible organisms resistant to other antimicrobials. Staphylococcal endocarditis, including septicemia, and infections of the lower respiratory tract, bone, and skin and skin structure. Streptococcal endocarditis due to S. viridans or S. bovis as monotherapy or in combination with an aminoglycoside. Enterococcal endocarditis due to E. faecalis in combination with an aminoglycoside. Diphtheroid endocarditis. Early-onset prosthetic valve endocarditis due to S. epidermidis or diphtheroids in combination with rifampin, or an aminoglycoside, or both.

Adult:

Give by intermittent IV infusion over at least 60 minutes or at a rate of 10mg/min or less, whichever is longer. 2g/day in divided doses (500mg every 6 hours or 1g every 12 hours). Renal impairment: adjust or reduce dose, obesity; see literature.

Children:

Give by intermittent IV infusion over at least 60 minutes. Neonates: ≤1 month: initially 15mg/kg, then 10mg/kg every 12 hours (for neonates in the 1st week of life) and every 8 hours thereafter (up to 1 month of age). >1 month: 10mg/kg per dose every 6 hours. Renal impairment: adjust or reduce dose, obesity; see literature.

Pharmacological Class:

Antibiotic.

Warnings/Precautions:

Renal insufficiency. Monitor hearing, blood, renal function. Monitor vancomycin serum concentrations closely. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Monitor with other ototoxic, nephrotoxic, neurotoxic drugs (eg, aminoglycosides, amphotericin B, bacitracin, polymyxin B, colistin, viomycin, cisplatin). Erythema, histamine-like flushing, anaphylactoid reactions may occur with concomitant anesthetic agents.

Adverse Reactions:

Infusion-related events, nausea, drug fever, rash (may be serious, eg, Stevens-Johnson syndrome), ototoxicity, nephrotoxicity, thrombophlebitis, blood dyscrasias; rare: interstitial nephritis, vertigo.

Note:

Formerly known under the brand name Vancocin.

How Supplied:

Contact supplier.

Indications for Vancomycin Inj:

Antibiotic-associated pseudomembranous colitis due to C. difficile.

Adult:

Dilute dose in 1oz of water and drink or give via nasogastric tube; 500mg–2g per day in 3–4 divided doses for 7–10 days. Renal impairment: adjust or reduce dose, obesity; see literature.

Children:

Dilute dose in 1 oz of water and drink or give via nasogastric tube; 40mg/kg per day in 3–4 divided doses for 7–10 days; max 2g/day. Renal impairment: adjust or reduce dose, obesity; see literature.

Pharmacological Class:

Antibiotic.

Warnings/Precautions:

Renal insufficiency. Monitor hearing, blood, renal function. Monitor vancomycin serum concentrations closely. Elderly. Debilitated. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Monitor with other ototoxic, nephrotoxic, neurotoxic drugs (eg, aminoglycosides, amphotericin B, bacitracin, polymyxin B, colistin, viomycin, cisplatin). Erythema, histamine-like flushing, anaphylactoid reactions may occur with concomitant anesthetic agents.

Adverse Reactions:

Nausea, drug fever, rash (may be serious, eg, Stevens-Johnson syndrome), ototoxicity, nephrotoxicity, blood dyscrasias; rare: interstitial nephritis, vertigo.

Note:

Formerly known under the brand name Vancocin.

How Supplied:

Contact supplier.

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