Select therapeutic use:
Indications for VANCOCIN:
Enterocolitis due to S. aureus. Antibiotic-associated pseudomembranous colitis due to C. difficile.
≥18yrs: 500mg–2g per day in 3–4 divided doses for 7–10 days. C. difficile-associated diarrhea: 125mg 4 times a day for 10 days.
40mg/kg per day in 3–4 divided doses for 7–10 days; max 2g/day.
Renal insufficiency and/or colitis. Inflammatory bowel disorders. Underlying hearing loss. Monitor hearing, blood, renal function. Consider monitoring vancomycin serum concentrations. Elderly. Pregnancy (Cat.B). Nursing mothers: not recommended.
Monitor with aminoglycosides, other neurotoxic, nephrotoxic, or ototoxic drugs.
Nausea, abdominal pain, hypokalemia, drug fever, urticaria, rash (may be serious, eg, Stevens-Johnson syndrome), ototoxicity, nephrotoxicity, eosinophilia, anaphylaxis, superinfection, blood dyscrasias; rare: interstitial nephritis, vertigo.