VALTURNA Rx

Indications for VALTURNA:

Hypertension, as monotherapy or with other antihypertensives. As initial therapy in patients likely to need multiple drugs to achieve blood pressure goals.

Adult Dose for VALTURNA:

Take consistently with regard to meals (absorption reduced by high-fat meals). 1 tablet once daily. Add-on or initial therapy and not volume-depleted: initially 150/160mg; may increase after 2–4 weeks to max 300/320mg. Replacement therapy: may be substituted for the titrated components.

Children's Dose for VALTURNA:

Not recommended.

Pharmacological Class:

Direct renin inhibitor + angiotensin II receptor blocker.

Contraindications:

Diabetes.

Warnings/Precautions:

Fetal toxicity may develop; discontinue if pregnancy is detected. Correct hypovolemia before starting, or start under close supervision. CHF. Recent MI. Severe heart failure in patients whose renal function depends on renin-angiotensin-aldosterone system. Moderate renal impairment (CrCl <60mL/min): avoid. Hepatic dysfunction. Renal artery stenosis. History of dialysis. Surgery. Monitor renal function, serum potassium periodically. Neonates. Pregnancy (Cat.D); avoid. Nursing mothers: not recommended.

Interactions:

Concomitant cyclosporine, itraconazole: not recommended. Hyperkalemia with NSAIDs, K⁺ supplements, K⁺ sparing diuretics, K⁺ containing salt supplements. May be antagonized by, and renal toxicity potentiated by NSAIDs (including COX-2 inhibitors): monitor renal function in elderly and/or volume-depleted. May be potentiated by inhibitors of hepatic uptake transporter OATP1B1 (eg, rifampin), or efflux transporter MRP2 (eg, ritonavir).

Adverse Reactions:

Fatigue, nasopharyngitis, GI upset; rare: hypotension, angioedema (discontinue if occurs).

How Supplied:

Tabs—30, 90