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URSO
Digestive and biliary disorders
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Drug Name:

URSO Rx

Generic Name and Formulations:
Ursodiol 250mg; tabs.

Company:
Aptalis Pharmaceutical Technologies



Therapeutic Use:

Indications for URSO:

Primary biliary cirrhosis.

Adult Dose for URSO:

Take with food. 13–15mg/kg per day in 2–4 divided doses.

Children's Dose for URSO:

Not established.

See Also:

URSO FORTE

Pharmacological Class:

Bile acid.

Contraindications:

Complete biliary obstruction.

Warnings/Precautions:

Variceal bleeding, hepatic encephalopathy, ascites, and/or need for an urgent liver transplant: give appropriate specific treatment. Monitor liver function and bilirubin monthly for 3 months after starting therapy, then every 6 months thereafter; consider discontinuing if levels increase significantly with history of stable liver function. Monitor and maintain bile flow. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Reduced absorption with bile acid sequestrants (eg, cholestyramine, colestipol), and aluminum-containing antacids. Estrogens, oral contraceptives, clofibrate, other lipid-lowering drugs may reduce effectiveness of ursodiol by increasing hepatic cholesterol secretion.

Adverse Reactions:

Abdominal discomfort or pain, alopecia, diarrhea, nausea, pruritus, rash, leukopenia, elevated creatinine or blood glucose, thrombocytopenia.

How Supplied:

Tabs—100; Forte—100

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