Primary biliary cirrhosis.
Take with food. 13–15mg/kg per day in 2–4 divided doses.
Variceal bleeding, hepatic encephalopathy, ascites, and/or need for an urgent liver transplant: give appropriate specific treatment. Pregnancy (Cat.B). Nursing mothers.
Reduced absorption with bile acid sequestrants (e.g., cholestyramine, colestipol), and aluminum-containing antacids. Estrogens, oral contraceptives, clofibrate, other lipid-lowering drugs may reduce effectiveness of ursodiol by increasing hepatic cholesterol secretion.
Leukopenia, rash, GI effects, elevated creatinine or blood glucose, thrombocytopenia.
Tabs—100, 500; Forte—100