Urological Disorders

Nephrologist Follow-Up Frequency Examined Post-Severe AKI

October 16, 2017

Respondents were asked to rank their likelihood of recommending follow-up for each patient after hospital discharge.

Drug Combo Efficacy Examined for Patients with HCV and Kidney Disease

October 12, 2017

"Treatment with glecaprevir and pibrentasvir for 12 weeks resulted in a high rate of sustained virologic response in patients with stage 4 or 5 chronic kidney disease and HCV infection," the authors write.

Lixivaptan Gets Orphan Drug Status for Autosomal Dominant PKD

By October 05, 2017

Lixivaptan is a potent, selective vasopressin V2 receptor antagonist which has been found to delay the progression of an autosomal dominant form of polycystic kidney disease.

Updated HCV Guidance Focuses on Additional Patient Populations

By October 03, 2017

The updates include a primer on HCV resistance and guidance on treating patients who have undergone kidney transplantation.

CKD-Mineral and Bone Disorder Treatment Recommendations Updated

By September 20, 2017

In addition, for adult patients with CKD G3a-G5 not on dialysis, the new guideline indicates that calcitriol and vitamin D analogs should not be routinely used.

Elevated Fibroblast Growth Factor 23 Not a Risk Factor in Early CKD

September 20, 2017

The risk for premature death increased by 62% and 42% for stage 3 CKD patients with vitamin D deficiency and elevated parathyroid hormone levels, respectively.

Sleep Duration, Quality Tied to Chronic Kidney Disease Progression

September 15, 2017

Shorter sleep duration, greater sleep fragmentation linked to greater decline in eGFR

Multiple Sclerosis Treatment Highlights

By September 13, 2017

MPR interviewed Dr. John Stoffel to discuss the strategies for diagnosis and management of urinary retention in MS patients, as well as his recommendations for optimal care for these patients.

Biomarkers ID'd That May Enhance Prediction of Renal Function Decline

September 11, 2017

The researchers found in an eGFR trajectory analysis that 10.1% of participants were rapid decliners, with a mean decrease of 2.9 mL/min/1.73 m²/year.

Intensive Blood Pressure Control Linked to Increased CKD Risk

September 08, 2017

However, cardiovascular events, all-cause mortality risk decrease with intensive blood pressure lowering

FDA Approves Unique Antibiotic Combo Drug Vabomere

By August 30, 2017

Vabomere is a combination antibiotic that includes meropenem, a penem antibacterial, and vaborbactam, a non-suicidal beta-lactamase inhibitor.

Infection Risk Higher with Worsening Kidney Function

August 21, 2017

The study focused on infections that people develop in the community, not hospitals and other health care settings.

Novel lgA Nephropathy Tx Gains Orphan Drug Status

By August 11, 2017

Phase 2 trials have shown to be associated with reductions in urine protein levels following treatment with OMS721 in patients with lgA nephropathy.

Corticosteroid Safety Assessed in IgA Nephropathy

August 02, 2017

Recruitment was discontinued because of excess serious adverse events after randomization of 262 participants.

Significant Sperm Count Decline in Western Men, Says Study

By July 28, 2017

Overall, between 1973 and 2011 the decline amounted to 52.4% (−1.38; −2.02 to −0.74; P<0.001) in sperm concentration.

Vaccine for Recurrent UTI Granted Fast Track Designation

By July 26, 2017

The vaccine consists of the FimH bacterial adhesion protein as well as a new adjuvant designed to induce an immune response to prevent bacterial colonization of the urinary tract.

Cephalosporin Antibiotic Formulation Discontinued

By July 24, 2017

Specifically, the following presentations will no longer be available: 125mg/5mL; 100mL bottles (anticipated final date of availability: April 1, 2018), 250mg/5mL; 50mL bottles (anticipated final date of availability: January 15, 2018), 250mg/5mL; 100mL bottles (anticipated final date of availability: February 15, 2018)

Testosterone Rx Behaviors Examined at Different Levels of Healthcare

July 24, 2017

"Our results highlight the opportunity to intervene both at the provider and the site level to improve testosterone prescribing," the authors write.

Value of Enhanced Recovery Protocol in Colon, Rectal Sx

July 11, 2017

Based on one retrospective review of 8 years of compliance, the strongest predictors of shorter length of stay were identified as no nasogastric tube, early mobilization, early oral nutrition, early removal of epidural and urinary catheter, and nonopioid analgesia.

Addition of Antifungal to Cancer Tx Leads to Nephrotic Syndrome

July 07, 2017

Case report of patient with relapsed Hodgkin's lymphoma treated with everolimus for five years

Astellas Seeks Approval for Overactive Bladder Combo Therapy

By June 30, 2017

"We look forward to FDA's review of our application for a potential new treatment option for the millions of people living with OAB," said Bernhardt Zeiher, MD, president of Development at Astellas.

Acupuncture Examined in Incontinence, Infertility

June 28, 2017

"The use of acupuncture with or without clomiphene, compared with control acupuncture and placebo, did not increase live births," the authors write.

Blood Protein Found to Identify Chronic Kidney Disease Risk

June 28, 2017

The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with two copies of APOL1 gene variants.

New White Paper on Nonneurogenic Chronic Urinary Retention

June 20, 2017

The researchers note that nonneurogenic chronic urinary retention was defined by the workgroup as an elevated post-void residual of more than 300mL, which persisted for at least 6 months and was documented on at least 2separate occasions.

Empagliflozin to Be Investigated in Chronic Kidney Disease

By June 12, 2017

In addition, the companies are conducting other mechanistic studies that will evaluate the potential mechanisms by which empagliflozin may affect renal outcomes in patients with CKD.

"UTI" Diagnosis May Lead to Harmful Antibiotic Overtreatment

By June 05, 2017

In their paper, the authors noted that "healthy urinary tracts host a ubiquitous, complex microbial community" and that the presence of these microorganisms are often beneficial to overall well-being.

Does Antioxidant Supplementation Slow Diabetic Kidney Disease Progression?

By June 02, 2017

Since oxidative stress is known to worsen DKD, study authors sought to review available data on the possible benefits of chronic antioxidant supplementation on DKD progression.

Sildenafil, Tadalafil Found in Herbal Coffee Supplement

By May 26, 2017

These undeclared ingredients may interact with nitrates contained in some prescription medications (eg, nitroglycerin), and may decrease blood pressure to dangerous levels.

AZO Line Expands with New Bladder Control Supplement

By May 23, 2017

The supplement contains pumpkin seed and soy germ extract, and Synetrim CQ, a botanical that further promotes bladder control by aiding metabolic health and managing weight.

PDE5 Inhibitors and Melanoma: What's the Risk?

By May 19, 2017

The association between melanoma among PDE5i users was only statistically significant for male patients with low PDE5i exposure and with low-stage melanoma.