Urological Disorders

Corticosteroid Safety Assessed in IgA Nephropathy

August 02, 2017

Recruitment was discontinued because of excess serious adverse events after randomization of 262 participants.

Significant Sperm Count Decline in Western Men, Says Study

By July 28, 2017

Overall, between 1973 and 2011 the decline amounted to 52.4% (−1.38; −2.02 to −0.74; P<0.001) in sperm concentration.

Vaccine for Recurrent UTI Granted Fast Track Designation

By July 26, 2017

The vaccine consists of the FimH bacterial adhesion protein as well as a new adjuvant designed to induce an immune response to prevent bacterial colonization of the urinary tract.

Cephalosporin Antibiotic Formulation Discontinued

By July 24, 2017

Specifically, the following presentations will no longer be available: 125mg/5mL; 100mL bottles (anticipated final date of availability: April 1, 2018), 250mg/5mL; 50mL bottles (anticipated final date of availability: January 15, 2018), 250mg/5mL; 100mL bottles (anticipated final date of availability: February 15, 2018)

Testosterone Rx Behaviors Examined at Different Levels of Healthcare

July 24, 2017

"Our results highlight the opportunity to intervene both at the provider and the site level to improve testosterone prescribing," the authors write.

Value of Enhanced Recovery Protocol in Colon, Rectal Sx

July 11, 2017

Based on one retrospective review of 8 years of compliance, the strongest predictors of shorter length of stay were identified as no nasogastric tube, early mobilization, early oral nutrition, early removal of epidural and urinary catheter, and nonopioid analgesia.

Addition of Antifungal to Cancer Tx Leads to Nephrotic Syndrome

July 07, 2017

Case report of patient with relapsed Hodgkin's lymphoma treated with everolimus for five years

Astellas Seeks Approval for Overactive Bladder Combo Therapy

By June 30, 2017

"We look forward to FDA's review of our application for a potential new treatment option for the millions of people living with OAB," said Bernhardt Zeiher, MD, president of Development at Astellas.

Acupuncture Examined in Incontinence, Infertility

June 28, 2017

"The use of acupuncture with or without clomiphene, compared with control acupuncture and placebo, did not increase live births," the authors write.

Blood Protein Found to Identify Chronic Kidney Disease Risk

June 28, 2017

The team found that elevated levels of the suPAR protein triggered the start and progression of chronic kidney disease in those with two copies of APOL1 gene variants.

New White Paper on Nonneurogenic Chronic Urinary Retention

June 20, 2017

The researchers note that nonneurogenic chronic urinary retention was defined by the workgroup as an elevated post-void residual of more than 300mL, which persisted for at least 6 months and was documented on at least 2separate occasions.

Empagliflozin to Be Investigated in Chronic Kidney Disease

By June 12, 2017

In addition, the companies are conducting other mechanistic studies that will evaluate the potential mechanisms by which empagliflozin may affect renal outcomes in patients with CKD.

"UTI" Diagnosis May Lead to Harmful Antibiotic Overtreatment

By June 05, 2017

In their paper, the authors noted that "healthy urinary tracts host a ubiquitous, complex microbial community" and that the presence of these microorganisms are often beneficial to overall well-being.

Does Antioxidant Supplementation Slow Diabetic Kidney Disease Progression?

By June 02, 2017

Since oxidative stress is known to worsen DKD, study authors sought to review available data on the possible benefits of chronic antioxidant supplementation on DKD progression.

Sildenafil, Tadalafil Found in Herbal Coffee Supplement

By May 26, 2017

These undeclared ingredients may interact with nitrates contained in some prescription medications (eg, nitroglycerin), and may decrease blood pressure to dangerous levels.

AZO Line Expands with New Bladder Control Supplement

By May 23, 2017

The supplement contains pumpkin seed and soy germ extract, and Synetrim CQ, a botanical that further promotes bladder control by aiding metabolic health and managing weight.

PDE5 Inhibitors and Melanoma: What's the Risk?

By May 19, 2017

The association between melanoma among PDE5i users was only statistically significant for male patients with low PDE5i exposure and with low-stage melanoma.

Topical Wipes Show Promise for Reducing Premature Ejaculation

May 16, 2017

After two months, men undergoing the treatment had significant improvement in intravaginal ejaculatory latency time than men on placebo.

E-Cigarette Use May Up Bladder Cancer Risk

By May 15, 2017

The researchers believe that based on their findings, e-cigarette smokers may be at increased risk for bladder cancer.

AUA 'Choosing Wisely' List IDs Unnecessary Tests, Treatments

By May 15, 2017

The 2017 AUA list contains evidence-based recommendations to guide conversations between physicians and patients about what care is appropriate.

FDA Grants Vonapanitase Breakthrough Therapy Status for Hemodialysis Use

By May 10, 2017

A second Phase 3 trial for vonapanitase in hemodialysis patients, PATENCY-2, is currently ongoing and is expected to complete enrollment in the first quarter of 2018.

Outcomes of Preventable Hospital-Acquired Complications Examined in CKD

May 01, 2017

Relative to patients without CKD or preventable HAC, the odds ratios for mortality during index hospitalization were 2.22, 5.26, and 9.56, respectively, for patients with CKD with no HAC, without CKD with HACs, and with CKD and HACs.

Italian-Style Coffee Consumption May Reduce Prostate Cancer Risk

By April 26, 2017

Nearly 7,000 Italian men participating in the Moli-sani epidemiological study aged ≥50 years were monitored for an average of 4.25 years.

Dietary Intervention Outcomes Examined in Chronic Kidney Disease

By April 24, 2017

Based on these studies, it would appear that dietary changes could prevent 1 in every 3,000 people treated for 1 year avoid ESKD, however the certainty in this effect was very low.

Veltassa Efficacy Assessed When Taken Without Food

By April 21, 2017

Results showed that 87.3% of the Veltassa plus food group and 82.5% of the Veltassa and no food group achieved and maintained potassium levels in the target range.

Overactive Bladder Tx Tied to Depressive Disorders

April 13, 2017

The researchers followed over 10,000 women for 3 years to assess the risk of depressive disorders associated with antimuscarinics.

Metabolic Outcomes in Trans Teens Receiving Cross-Sex Hormones

April 12, 2017

The researchers found that of the 72 subjects taking testosterone, at each visit significant increases in hemoglobin/hematocrit levels and BMI were recorded, as was a decrease in high-density lipoprotein level.

USPSTF Drafts Prostate CA Screening Recommendations

By April 11, 2017

The USPSTF performed a systematic review of the existing evidence and concluded that the potential benefits and harms of prostate-specific antigen (PSA)-based screening are "closely balanced" in men aged 55-69 years.

Botox Injection Efficacy Examined in Overactive Bladder

April 10, 2017

The researchers found that for treatment of overactive bladder, the safety and efficacy of intradetrusor injection of onabotulinumtoxin A is sensitive to injection volume and depth.

pH-Balanced Vaginal Gel Assessed for Dyspareunia in Breast CA Survivors

April 10, 2017

The researchers found that both groups experienced a significant improvement of dyspareunia, with no difference between the groups.