Urological Disorders

Antiretroviral Combination Linked to Increased CKD Risk

By December 08, 2017

The risk of chronic kidney disease (CKD) may be increased in patients living with HIV receiving tenofovir (TDF) with a ritonavir-boosted protease inhibitor compared to those who receive TDF with a non-nucleosidic reverse transcriptase inhibitor (NNRTI)

Congenital Adrenal Hyperplasia Treatment Granted Orphan Drug Status

By December 07, 2017

CAH is a rare endocrine disorder caused by genetic mutations which result in an inability to produce cortisol.

Possible New Marker of Kidney Disease Identified in Sickle Cell

December 05, 2017

Subsequently, 18 extracellular proteins were focused on, including CP, a protein involved in iron metabolism.

Urinary Incontinence

November 29, 2017

Types of urinary incontinence and its potential causes.

Does Sodium Bicarbonate Benefit Patients With Impaired Kidney Function Undergoing Angiography?

November 14, 2017

A total of 5,177 patients at high risk for renal complications were randomized and scheduled for angiography to receive intravenous sodium bicarbonate or sodium chloride and 5 days of oral acetylcysteine or placebo.

NSAID Compared to Antibiotic for Symptomatic Treatment of UTI

By November 09, 2017

The primary endpoint of symptom resolution at day 3 was met by 54% (72/133) in the diclofenac group vs. 80% (96/120) in the norfloxacin group (risk difference 27%, 95% CI 15% to 38%, P=0.98 for non-inferiority, P<0.001 for superiority).

Sertraline May Not Benefit Non-Dialysis Dependent CKD Patients With MDD

November 07, 2017

The researchers found that there was a change in the 16-item Quick Inventory of Depression Symptomatology-Clinician Rated of −4.1 in the sertraline group and −4.2 in the placebo group.

Tolvaptan Slows Loss of Renal Function in Later-Stage ADPKD

November 06, 2017

Reduction in decline in eGFR for patients with later-stage autosomal dominant polycystic kidney disease

Uric Acid-Lowering Therapy May Improve Renal Outcomes in CKD Patients

By November 03, 2017

Uric acid-lowering therapy might improve kidney outcomes, including kidney failure events, proteinuria, and the rate of change in eGFR, and seem to reduce the risk of cardiovascular events in adults with CKD.

New Data Show Canagliflozin May Improve Renal Outcomes in T2DM Patients

By November 03, 2017

The renal analyses showed that compared to placebo, canagliflozin reduced the risk of kidney disease progression, including significantly reducing urinary albumin excretion and stabilizing estimated glomerular filtration rate (eGFR) over a study duration of more than six years.

Regular Coffee Consumption May Aid Chronic Kidney Disease Patients

November 03, 2017

Compared with individuals in the first quartile of caffeine consumption, those in the second, third, and fourth quartiles had adjusted hazard ratios for mortality of 0.88.

Nephrologist Follow-Up Frequency Examined Post-Severe AKI

October 16, 2017

Respondents were asked to rank their likelihood of recommending follow-up for each patient after hospital discharge.

Drug Combo Efficacy Examined for Patients with HCV and Kidney Disease

October 12, 2017

"Treatment with glecaprevir and pibrentasvir for 12 weeks resulted in a high rate of sustained virologic response in patients with stage 4 or 5 chronic kidney disease and HCV infection," the authors write.

Lixivaptan Gets Orphan Drug Status for Autosomal Dominant PKD

By October 05, 2017

Lixivaptan is a potent, selective vasopressin V2 receptor antagonist which has been found to delay the progression of an autosomal dominant form of polycystic kidney disease.

Updated HCV Guidance Focuses on Additional Patient Populations

By October 03, 2017

The updates include a primer on HCV resistance and guidance on treating patients who have undergone kidney transplantation.

CKD-Mineral and Bone Disorder Treatment Recommendations Updated

By September 20, 2017

In addition, for adult patients with CKD G3a-G5 not on dialysis, the new guideline indicates that calcitriol and vitamin D analogs should not be routinely used.

Elevated Fibroblast Growth Factor 23 Not a Risk Factor in Early CKD

September 20, 2017

The risk for premature death increased by 62% and 42% for stage 3 CKD patients with vitamin D deficiency and elevated parathyroid hormone levels, respectively.

Sleep Duration, Quality Tied to Chronic Kidney Disease Progression

September 15, 2017

Shorter sleep duration, greater sleep fragmentation linked to greater decline in eGFR

Multiple Sclerosis Treatment Highlights

By September 13, 2017

MPR interviewed Dr. John Stoffel to discuss the strategies for diagnosis and management of urinary retention in MS patients, as well as his recommendations for optimal care for these patients.

Biomarkers ID'd That May Enhance Prediction of Renal Function Decline

September 11, 2017

The researchers found in an eGFR trajectory analysis that 10.1% of participants were rapid decliners, with a mean decrease of 2.9 mL/min/1.73 m²/year.

Intensive Blood Pressure Control Linked to Increased CKD Risk

September 08, 2017

However, cardiovascular events, all-cause mortality risk decrease with intensive blood pressure lowering

FDA Approves Unique Antibiotic Combo Drug Vabomere

By August 30, 2017

Vabomere is a combination antibiotic that includes meropenem, a penem antibacterial, and vaborbactam, a non-suicidal beta-lactamase inhibitor.

Infection Risk Higher with Worsening Kidney Function

August 21, 2017

The study focused on infections that people develop in the community, not hospitals and other health care settings.

Novel lgA Nephropathy Tx Gains Orphan Drug Status

By August 11, 2017

Phase 2 trials have shown to be associated with reductions in urine protein levels following treatment with OMS721 in patients with lgA nephropathy.

Corticosteroid Safety Assessed in IgA Nephropathy

August 02, 2017

Recruitment was discontinued because of excess serious adverse events after randomization of 262 participants.

Significant Sperm Count Decline in Western Men, Says Study

By July 28, 2017

Overall, between 1973 and 2011 the decline amounted to 52.4% (−1.38; −2.02 to −0.74; P<0.001) in sperm concentration.

Vaccine for Recurrent UTI Granted Fast Track Designation

By July 26, 2017

The vaccine consists of the FimH bacterial adhesion protein as well as a new adjuvant designed to induce an immune response to prevent bacterial colonization of the urinary tract.

Cephalosporin Antibiotic Formulation Discontinued

By July 24, 2017

Specifically, the following presentations will no longer be available: 125mg/5mL; 100mL bottles (anticipated final date of availability: April 1, 2018), 250mg/5mL; 50mL bottles (anticipated final date of availability: January 15, 2018), 250mg/5mL; 100mL bottles (anticipated final date of availability: February 15, 2018)

Testosterone Rx Behaviors Examined at Different Levels of Healthcare

July 24, 2017

"Our results highlight the opportunity to intervene both at the provider and the site level to improve testosterone prescribing," the authors write.

Value of Enhanced Recovery Protocol in Colon, Rectal Sx

July 11, 2017

Based on one retrospective review of 8 years of compliance, the strongest predictors of shorter length of stay were identified as no nasogastric tube, early mobilization, early oral nutrition, early removal of epidural and urinary catheter, and nonopioid analgesia.