Urinary Tract Discomfort

NSAID Compared to Antibiotic for Symptomatic Treatment of UTI

By November 09, 2017

The primary endpoint of symptom resolution at day 3 was met by 54% (72/133) in the diclofenac group vs. 80% (96/120) in the norfloxacin group (risk difference 27%, 95% CI 15% to 38%, P=0.98 for non-inferiority, P<0.001 for superiority).

FDA Approves Unique Antibiotic Combo Drug Vabomere

By August 30, 2017

Vabomere is a combination antibiotic that includes meropenem, a penem antibacterial, and vaborbactam, a non-suicidal beta-lactamase inhibitor.

Cephalosporin Antibiotic Formulation Discontinued

By July 24, 2017

Specifically, the following presentations will no longer be available: 125mg/5mL; 100mL bottles (anticipated final date of availability: April 1, 2018), 250mg/5mL; 50mL bottles (anticipated final date of availability: January 15, 2018), 250mg/5mL; 100mL bottles (anticipated final date of availability: February 15, 2018)

"UTI" Diagnosis May Lead to Harmful Antibiotic Overtreatment

By June 05, 2017

In their paper, the authors noted that "healthy urinary tracts host a ubiquitous, complex microbial community" and that the presence of these microorganisms are often beneficial to overall well-being.

AUA 'Choosing Wisely' List IDs Unnecessary Tests, Treatments

By May 15, 2017

The 2017 AUA list contains evidence-based recommendations to guide conversations between physicians and patients about what care is appropriate.

Positive Results for Plazomicin for cUTI, CRE Infections

By December 12, 2016

Achaogen has announced positive results from the Phase 3 trials ('EPIC' and 'CARE') of plazomicin, a lead candidate for potential treatment of complicated urinary tract infections (cUTI) and acute pyelonephritis (AP).

Guidelines for UTI in Febrile Infants and Young Children Reaffirmed

November 29, 2016

2011 CPG on urinary tract infection in infants and young children reaffirmed after review of literature

UTI Treatment Leads to Fatal Drug Interaction in a Schizophrenia Patient

By November 23, 2016

This case is the first to describe a fatal outcome with such an interaction.

Year Long Study Examines Efficacy of Cranberry Capsules in Preventing UTIs

October 28, 2016

There is no significant difference in the presence of bacteriuria plus pyuria over one year among older women living in nursing homes receiving cranberry capsules versus a placebo pill, according to a study published online October 27 in the Journal of the American Medical Association. The research was published to coincide with the annual meeting of the Infectious Diseases Society of America (IDWeek), held from Oct. 26 to 30 in New Orleans.

Treatment of UTI Leads to Fatal Hepatotoxicity

By October 19, 2016

This antibiotic class is rarely linked to liver injury.

Study IDs Urinalysis Marker for UTI Diagnosis in Young Adults

October 19, 2016

For infants undergoing microscopic urinalysis as part of urinary tract infection (UTI) evaluation, urine concentration should be included in the interpretation, according to a study published online in Pediatrics.

FDA to Review New Data for Avycaz in Complicated UTI

By October 14, 2016

The Food and Drug Administration (FDA) has accepted a supplemental New Drug Application (sNDA) for Avycaz (ceftazidime and avibactam; Allergen), for the addition of new Phase 3 data to the label.

Reasons for Inappropriate Antibiotic Prescribing Explored in Elderly

September 29, 2016

Constitutional symptoms, including mentation, often lead to diagnostic testing and potentially inappropriate antibiotic prescribing in older patients suspected of having a urinary tract infection (UTI) or pneumonia, according to a study published online in the Journal of the American Geriatrics Society.

Bacteriuria ID'd as Possible Trigger of Higher Edema Incidence

August 25, 2016

For patients with hereditary angioedema due to C1-inhibitor deficiency (C1-INH-HAE), those with bacteriuria have a higher number of edematous attacks, according to a study published online in Allergy.

High Specificity, Low Sensitivity in Onsite Tests for Asymptomatic Bacteriuria

August 15, 2016

Onsite tests have high specificity for detecting asymptomatic bacteriuria among pregnant women, but sensitivity is lower, according to a review published in the September issue of Obstetrics & Gynecology.

Over Half of Pediatric Patients with UTI Resistant to Antibiotic, Study Finds

March 17, 2016

Many children who develop urinary tract infections (UTIs) tied to the Escherichia coli bacteria are now failing to respond to antibiotic treatment, according to research published online March 15 in The BMJ.

Stone Removal May Not Help All Patients for Recurrent UTI

September 28, 2015

Half of patients with recurrent urinary tract infections and asymptomatic renal calculi can be rendered infection-free with stone extraction, according to a study published in The Journal of Urology.

Cranberry Juice Capsules May Cut UTI Risk After Gynecological Surgery

July 30, 2015

Cranberry juice capsules may reduce the rate of urinary tract infection (UTI) in women undergoing elective benign gynecological surgery involving urinary catheterization.

Nocturia, Reassurance Key Drivers for Men Seeking LUTS Care

July 01, 2015

Overall, men with LUTS showed remarkably poor knowledge about their symptoms

Brain Abnormalities Linked to Interstitial Cystitis/Bladder Pain Syndrome

June 19, 2015

Brain abnormalities linked to symptoms of interstitial cystitis/bladder pain syndrome

AUA Discusses Antimicrobials, PSA Testing in New <i>Choosing Wisely</i> Recommendations

By June 12, 2015

The American Urological Association (AUA) has issued a new list of recommendations as part of the Choosing Wisely campaign.

Common Rx for UTIs in Older Women May Not Be Best Choice

May 01, 2015

Nitrofurantoin may not be the most effective option for treatment of urinary tract infections in older women, according to a new new study.

Cranberries May Be as Effective in UTI Prevention as Antibiotics, Study Finds

By April 28, 2015

Cranberry extract may lower the risk of urinary tract infection (UTI) by 50% in women who have a catheter in place while undergoing elective gynecological surgery.

Bullying Linked to LUTS in Children

January 20, 2015

For 8 to 11-year-olds, bullying is associated with lower urinary tract symptoms.

New Inj Combo Antibiotic Approved for Complicated UTI, IAI

By December 22, 2014

Cubist announced that the Food and Drug Administration (FDA) has approved Zerbaxa (ceftolozane/tazobactam) Injection for the treatment of adults with complicated urinary tract infections (cUTI) and complicated intra-abdominal infections (cIAI) caused by susceptible Gram-negative bacteria.

Adherence to AUA BPH Guidelines Varies

October 21, 2014

Researchers have evaluated urologist adherence to the American Urological Association (AUA) guidelines for the management of benign prostatic hyperplasia (BPH)-related lower urinary tract symptoms (LUTS).

Half of Hospital Patients Receive At Least One Antibiotic

October 08, 2014

About half of all U.S. hospital patients receive antibiotics, and these drugs are commonly the ones more likely to promote the growth of antibiotic-resistant bacteria, according to a new study.

Can Tamsulosin Improve Urinary Symptoms in Women with Dysfunctional Voiding, Recurrent UTI?

September 09, 2014

Because α1-AR appear to have a role in lower urinary tract function, the use of α1-AR antagonists like tamsulosin may be effective for female patients with dysfunctional voiding.

Relebactam Designated Qualified Infectious Disease Product Status for Complicated Infections

September 04, 2014

The Food and Drug Administration (FDA) has granted Qualified Infectious Disease Product with designated Fast Track status to relebactam (MK-7655; Merck) for intravenous use, in the treatment complicated urinary tract infections, complicated intra-abdominal infections, and hospital-acquired bacterial pneumonia/ventilator-associated bacterial pneumonia.

Eravacycline Efficacious in Complicated Urinary Tract Infections Study

September 03, 2014

Tetraphase announced positive results from the lead-in portion of its IGNITE 2 clinical trial with IV and oral formulations of eravacycline for the treatment of complicated urinary tract infections (cUTI).