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TRILIPIX
Hyperlipoproteinemias
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Drug Name:

TRILIPIX Rx

Generic Name and Formulations:
Fenofibric acid (as choline fenofibrate) 45mg, 135mg; del-rel caps.

Company:
AbbVie

e-Prescribe this drug via Surescripts


Therapeutic Use:

Indications for TRILIPIX:

Adjunct to diet: In combination with a statin, to reduce triglycerides (TG) and increase high-density lipoprotein cholesterol (HDL-C) in patients with mixed dyslipidemia and CHD or a CHD risk equivalent who are on optimal statin therapy to achieve LDL-C goal; As monotherapy to reduce TG in severe hypertriglyceridemia, and to reduce elevated LDL-C, total cholesterol (total-C), TG, and apolipoprotein B (Apo B), and to increase HDL-C in primary hyperlipidemia or mixed dyslipidemia.

Adult Dose for TRILIPIX:

Swallow whole. Mixed dyslipidemia, primary hyperlipidemia: 135mg once daily. Hypertriglyceridemia: 45–135mg once daily. Titrate at 4–8week intervals; max 135mg/day. Mild to moderate renal impairment: initially 45mg once daily.

Children's Dose for TRILIPIX:

Not established.

Pharmacological Class:

Fibrate.

Contraindications:

Severe renal dysfunction (including dialysis). Active liver disease. Primary biliary cirrhosis. Unexplained persistent liver function abnormalities. Gallbladder disease. Nursing mothers.

Warnings/Precautions:

The effect on coronary heart disease morbidity and mortality and non-cardiovascular mortality has not been established. Renal failure, diabetes, hypothyroidism, elderly: increased risk of myopathy with concomitant statins. Discontinue if markedly elevated CPK levels occur or myopathy or myositis is suspected. Monitor liver function; discontinue if LFTs >3xULN persist. Renal impairment: monitor renal function. Discontinue therapy if gallstones are found. Check HDL-C levels within first few months after initiating therapy; withdraw if severely depressed levels detected, monitor and do not re-initate. Pregnancy (Cat.C).

Interactions:

Avoid with max doses of a statin (myopathy). Potentiates warfarin (monitor). Separate dosing of bile acid sequestrants. Caution with cyclosporine, tacrolimus, colchicine.

Adverse Reactions:

Headache, back pain, nasopharyngitis, nausea, myalgia, diarrhea, URI, elevated LFTs, serum creatinine; myopathy, rhabdomyolysis, hematological changes (eg, hgb, hct), cholelithiasis, pancreatitis, possible hypersensitivity reactions.

Metabolism:

Hepatic; 99% protein bound.

Elimination:

Renal.

Generic Availability:

YES

How Supplied:

Caps—30, 90

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