TRICOR Rx

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TRICOR

Hyperlipoproteinemias
Only 4 drugs may be compared at once

Generic Name and Formulations:

Fenofibrate 48mg, 145mg; tabs.

Company:

AbbVie

Select therapeutic use:

Indications for TRICOR:

Adjunct to diet in hypertriglyceridemia (Types IV and V), and to reduce elevated total-C, LDL-C, apo B, and TG, and to increase HDL-C, in primary hypercholesterolemia and mixed dyslipidemia (Types IIa and IIb). Limitations of use: not shown to reduce coronary heart disease morbidity and mortality in a controlled trial of patients with type 2 diabetes mellitus.

Adult:

Hypertriglyceridemia: 48–145mg/day, adjust at 4–8 week intervals. Hypercholesterolemia, dyslipidemia: 145mg/day. Renal impairment or elderly: initially 48mg/day. Discontinue if inadequate response after 2 months on max dose.

Children:

Not recommended.

Contraindications:

Hepatic dysfunction. Primary biliary cirrhosis. Severe renal dysfunction. Gallbladder disease.

Warnings/Precautions:

Renal impairment. Monitor CBCs for first year; monitor liver function; discontinue if ALT (SGPT) levels >3xULN persist. Discontinue if markedly elevated CPK levels, myopathy, gallstones or severely depressed HDL-C levels occur (do not reinitiate). Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid statins. Potentiates oral anticoagulants (monitor). Allow at least 1 hour before or 4–6 hours after bile acid sequestrants. Caution with immunosuppressants (eg, cyclosporine), colchicine, other nephrotoxic drugs.

Pharmacological Class:

Fibrate.

Adverse Reactions:

Abnormal liver function tests, elevated CPK, rhinitis, myopathy, cholelithiasis, pancreatitis, increased BUN or creatinine, rash; rare: rhabdomyolysis, transient hematologic changes, blood dyscrasias.

Generic Availability:

YES

How Supplied:

Tabs—90

TRICOR 145mg tablets (Qty:30)

appx. price $38.00