No benefit of sodium bicarbonate or acetylcysteine for prevention of complications after angiography
Amongst patients undergoing angiography, neither sodium bicarbonate nor acetylcysteine were effective in preventing a composite outcome of death, need for dialysis, or persistent kidney injury.
No increased risk of incident epilepsy was seen among children who received influenza vaccination during the 2009-2010 influenza season in Norway.
In this study about quality of care for patients with TIA or minor stroke, there was substantial variation in adherence to guidelines for patients treated at Veteran's Affairs (VA) hospitals across the country.
Adults with chronic kidney disease (CKD) and heart failure with reduced LVEF who received implantable cardioverter defibrillators (ICDs) did not differ from matched non-ICD patients with relation to all-cause mortality.
In patients with nocturnal symptoms of post-traumatic stress disorder (PTSD), prazosin did not significantly reduce nightmares or improve quality of sleep compared to placebo at 10 or 26 weeks.
National sudden unexpected infant death (SUID) rates had the steepest decline during the 1990 to 1998 study time period, followed by slower decline during 1999 to 2015.
A preoperatively diagnosed patent foramen ovale was associated with an increased risk of stroke within 30 days of non-cardiac surgery. With Evidence Rating Level: 2 (Good).
Nearly twice the number of youths who identify as transgender or gender nonconforming (TGNC) stated their health to be fair, poor, or good as opposed to very good or excellent when compared with youths who identified as cisgender.
A device for islet transplantation for type 1 diabetes was designed and demonstrated to be safe and retrievable in animal models.
Recurrent Salmonella enterica Typhimurium infection disables host protection against intestinal inflammation
Repeated gastrointestinal infections in mice, in this case Salmonella enterica Typhimurium (ST), caused intestinal tissue inflammation which escalated with repeated infections.
Patients with sleep apnea achieve similar outcomes when receiving care from a sleep specialist or nonspecialist
Obstructive sleep apnea (OSA) patients have similar outcomes regardless of sleep specialist or non-specialist care.
In this analysis of healthcare spending survey data from a nationally represented sample, the implementation of the Affordable Care Act (ACA) was associated with a decrease in mean out-of-pocket spending for healthcare. Mean premium spending increased during this same time period.
In a self-controlled case series, patients were observed to have increased incidence of hospital admissions for acute myocardial infarction (MI) within seven-days of respiratory virus detection.
Infants classified as very high risk for substantiated maltreatment had a higher relative risk of overall mortality, death through unintentional and inflicted injury, and sudden unexpected infant death.
Scleroderma patients treated with myeloablative autologous stem-cell transplantation experienced significantly higher rates of disease-free survival at 52 months post-treatment compared to those treated with cyclophosphamide.
In 2010, prior to the Zika virus epidemic, microcephaly rates were noted to be elevated in 2 Brazilian cities.
Thrombectomy performed between 6 and 24 hours after onset of acute stroke in patients with a mismatch between stroke symptoms and infarct volume results in better disability outcomes compared to standard care alone.
Never-cigarette-smoking youths who initiated tobacco use with noncigarette products including e-cigarettes, hookahs, noncigarette combustible tobacco, or smokeless tobacco were more likely to smoke cigarettes in the following year than those who did not use noncigarette tobacco.
Systemic atherosclerosis linked with intracranial atherosclerotic disease-related stroke and worse prognosis
In patients with stroke who had intracranial atherosclerotic disease (ICAD), atherosclerotic disease in other vascular beds was more common including the aortic arch and coronary artery disease.
Regional variation in cumulative risk of an individual having a chest or abdominal CT in the United States was positively correlated with the risk of both total and partial nephrectomy, as well as any renal procedure (including renal ablation).
Outcomes after left ventricular assist device implantation significantly worse for those with end-stage renal disease
Patients with end-stage renal disease (ESRD) have significantly worse survival outcomes following left ventricular assist device (LVAD) implantation compared to recipients without ESRD.
Through this retrospective study, researchers found that 0.42% of study infants undergoing CSF culture for suspected meningitis tested positive for herpes simplex virus (HSV) infection. HSV infection was more common in infants aged 1-4 weeks when compared to infants from age 5-9 weeks.
Patients with a legacy pacemaker or cardioverter-defibrillator were followed after undergoing medically indicated magnetic resonance imaging (MRI) examinations, and no long-term clinically significant adverse effects were reported.
Chimeric antigen receptor T-cell therapy elicits treatment response in patients with refractory B-cell lymphoma
Patients with refractory diffuse large B-cell or follicular lymphoma demonstrated high rates of remission when treated with anti-CD19 directed chimeric antigen receptor (CAR) T-cell therapy.
Compared to placebo, letermovir prophylaxis significantly decreased the incidence of cytomegalovirus (CMV) infection through 24 weeks following hematopoietic stem cell transplantation (HSCT).
Reduced mortality with culprit-lesion-only percutaneous coronary intervention for acute myocardial infarction with cardiogenic shock
In patients with acute myocardial infarction (MI) with cardiogenic shock and multivessel coronary disease, culprit-lesion-only percutaneous coronary intervention (PCI) had a lower risk of 30-day mortality compared to multivessel PCI.
Hillier, SL et al. "Secnidazole Treatment of Bacterial Vaginosis: A Randomized Controlled Trial." DOI: 10.1097/AOG.0000000000002135
Fizazi, K et al. "Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer." DOI: 10.1056/NEJMoa1704174
Maio, M et al. "Tremelimumab as second-line or third-line treatment in relapsed malignant mesothelioma (DETERMINE): a multicentre, international, randomised, double-blind, placebo-controlled phase 2b trial." DOI: http://dx.doi.org/10.1016/S1470-2045(17)30446-1
Kil, J et al. "Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial." DOI: http://dx.doi.org/10.1016/S0140-6736(17)31791-9