Trial Tracker

Rates of neurodevelopmental impairment unchanged in infants born ≤500g in Japan

November 16, 2018

Accurate data on long-term neurodevelopmental outcomes is critical for families and physicians to make informed decisions regarding resuscitation and care of these infants.

Sensitive cardiac injury marker could reduce stress testing for myocardial ischemia

November 12, 2018

Routine surveillance stress testing is often costly and overused. Furthermore, current guidelines recommend against routine stress testing in patients with stable ischemic CAD, unless the purpose of the test is to assess new or progressive symptoms.

Inhaled inorganic nitrites do not improve exercise capacity in HFpEF

November 09, 2018

Past studies have suggested the possible utility of organic nitrates/inorganic nitrites in treating Heart Failure with preserved Ejection Fraction.

Organic food consumption linked to reduced cancer risk

November 07, 2018

This study is a prospective cohort that evaluated self-reported organic food consumption and incidence of cancer, while adjusting for known cancer risk factors.

Outcomes of hypertension treatment in low-risk patients

November 05, 2018

The benefit of treating low-risk patients with mild (sustained blood pressure of 140/90-159/99mmHg) hypertension is not clear as these patients are not frequently included in trials given the low incidence rate of major cardiovascular events.

Sildenafil does not improve QoL for idiopathic pulmonary fibrosis patients treated with nintedanib

November 02, 2018

In patients with idiopathic pulmonary fibrosis (IPF) and a low diffusion capacity for carbon dioxide (DLCO), the addition of sildenafil to a treatment regimen of nintedanib did not improve quality of life scores after 12 weeks compared to treatment with nintedanib and a placebo.

Gastric bypass most effective for weight loss among common bariatric procedures

October 31, 2018

Roux-en-Y gastric bypass was found to be the most effective bariatric procedure reviewed in this study in terms of patient weight loss.

ACP updates policy recommendations for reducing gun-related injuries, deaths

October 30, 2018

The American College of Physicians (ACP) revises and expands on current policy recommendations regarding gun-related injuries and deaths.

Medical vaccine exemptions increase after elimination of nonmedical exemptions

October 29, 2018

After California eliminated nonmedical exemptions from school-entry vaccinations in 2015, the proportion of kindergarten students who received all required vaccines rose from 92.8% to 95.1%, but the rates of medical exemptions increased 250%.

Presence of antiphospholipid antibodies important risk factor for myocardial infarction

October 26, 2018

A positive association was found between the antiphospholipid antibody immunoglobulin G and first-time myocardial infarctions in study patients.

Algorithm safely rules out pulmonary embolism in pregnant women

October 26, 2018

A diagnostic model based on D-dimer measurement, lower limb compression ultrasonography (CUS) and computed tomography pulmonary angiography (CTPA) accurately ruled out pulmonary embolism (PE) in pregnancy.

Intensive blood pressure lowering favored to not induce kidney disease

October 26, 2018

Patients managed with intensive blood pressure reduction were found to have significantly greater decreases in kidney damage biomarkers compared to standard blood pressure management.

No benefit of myo-inositol on type 1 retinopathy of prematurity in preterm Infants

By October 24, 2018

In this randomized controlled trial, both mortality and retinopathy of prematurity (ROP) type 1 occurred more often in preterm infants treated with myo-inositol than in those treated with placebo.

ICU admissions among Medicare beneficiaries on a decade-long downward trend

October 19, 2018

Intensive care unit (ICU) admission rates decreased from 2006 to 2015.

Early, delayed renal-replacement examined in septic shock associated acute kidney injury

October 19, 2018

Among patients with septic shock and acute kidney injury, there was no significant difference in 90-day mortality between early (within 12 hours) and delayed (after 48 hours) initiation of renal-replacement therapy (RRT).

Effect of Immediate vs Delayed Pushing on Rates of Spontaneous Vaginal Delivery

October 17, 2018

Although more than 3 million women give birth in the US each year, there is no consensus regarding the optimal timing of maternal pushing during the second stage of labor (defined as the time from complete cervical dilation to delivery of the fetus).

Use of NSAIDs for musculoskeletal pain not linked with adverse outcomes

October 13, 2018

In this retrospective cohort analysis, patients with a history of hypertension, chronic kidney disease, or heart failure presenting to primary care physicians for musculoskeletal complaints were frequently prescribed NSAIDs.

Continuous, extended combined oral contraceptive regimens and VTE risk

October 11, 2018

In this retrospective cohort study, continuous (84/7) or extended (365/0) cycle regimens of combined oral contraceptives were not linked with meaningfully higher rates of venous thromboembolism (VTE) when compared with traditional cyclic (21/7) regimens.

Acetaminophen reduces febrile seizure recurrence in children within same fever episode

October 08, 2018

Rectal acetaminophen reduces rates of second febrile seizure in children during the course of the same febrile illness when given rectally soon after initial seizure.

Bariatric surgery linked to significant reduction in microvascular complications of T2D

August 10, 2018

Patients who received gastric bypass surgery had lower rates of diabetic neuropathy at follow up that remained stable throughout the study.

Neonatal neuroimaging and predictive value for developmental outcomes

June 26, 2018

In multivariate analyses, adverse late cranial ultrasound findings (CUS) were an independent risk factor for full scale IQ scores 70 (FSIQ 70). Adverse late cranial ultrasound findings and adverse findings on MRI were independent risk factors for moderate-to-severe disability (MTSD).

Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization

June 25, 2018

The majority of buprenorphine exposures in children 19 years and younger reported to the National Poison Data System (NPDS) were among children 6 years old and unintentional. However, the majority of exposures among adolescents aged 13 to 19 years were intentional and more commonly involved multiple substances.

Prenatal antidepressant exposure may increase risk of poor motor development

June 21, 2018

A meta-analysis of 18 studies examining the association of prenatal antidepressant exposure with motor development in children showed a small overall effect of worse motor development outcomes among children exposed to antidepressants in pregnancy.

Failures in using personal protective equipment are commonly observed

June 20, 2018

In this qualitative study, active failures in infectious agent transmission precaution practices were observed frequently.

Disparities in adolescent physical activity between sex, race, and income

June 20, 2018

In this study of the patterns of physical activity in adolescents and young adults, young age, white race, and higher income were all associated with greater physical activity.

Lack of superiority of rivaroxaban for secondary prevention of embolic stroke of undetermined source

June 19, 2018

At a median follow-up of eleven months, rivaroxaban was not superior to aspirin for prevention of secondary stroke after an initial primary embolic stroke of undetermined source.

Prognosis of extremely premature infants linked to inherent selection bias

June 19, 2018

Demographic data, such as larger birth weight and female gender, of infants born at 23 weeks' gestation were shown to influence the chance that active resuscitation was initiated.

Medications with depression as a possible adverse effect associated with increased risk

June 15, 2018

In this cross-sectional study, the use of medications with depression as an adverse effect was associated with a higher prevalence of depression while a similar association was not observed for medications without depression as a possible side effect.

Lower and higher oxygen saturation targets result in equal but contrasting outcomes for preemies

June 14, 2018

In this meta-analysis, there was no significant difference between lower and higher oxygen saturation targets on a primary composite of mortality or major disability at a corrected age of 18-24 months for infants born extremely preterm.

No benefit of negative pressure wound therapy for lower extremity fractures

June 14, 2018

In this randomized controlled trial, there was no difference in the self-reported disability 12 months after injury between patients treated with negative pressure wound therapy (NPWT) and those treated standardardly.