Trial Tracker

Bariatric surgery linked to significant reduction in microvascular complications of T2D

August 10, 2018

Patients who received gastric bypass surgery had lower rates of diabetic neuropathy at follow up that remained stable throughout the study.

Neonatal neuroimaging and predictive value for developmental outcomes

June 26, 2018

In multivariate analyses, adverse late cranial ultrasound findings (CUS) were an independent risk factor for full scale IQ scores 70 (FSIQ 70). Adverse late cranial ultrasound findings and adverse findings on MRI were independent risk factors for moderate-to-severe disability (MTSD).

Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization

June 25, 2018

The majority of buprenorphine exposures in children 19 years and younger reported to the National Poison Data System (NPDS) were among children 6 years old and unintentional. However, the majority of exposures among adolescents aged 13 to 19 years were intentional and more commonly involved multiple substances.

Prenatal antidepressant exposure may increase risk of poor motor development

June 21, 2018

A meta-analysis of 18 studies examining the association of prenatal antidepressant exposure with motor development in children showed a small overall effect of worse motor development outcomes among children exposed to antidepressants in pregnancy.

Failures in using personal protective equipment are commonly observed

June 20, 2018

In this qualitative study, active failures in infectious agent transmission precaution practices were observed frequently.

Disparities in adolescent physical activity between sex, race, and income

June 20, 2018

In this study of the patterns of physical activity in adolescents and young adults, young age, white race, and higher income were all associated with greater physical activity.

Lack of superiority of rivaroxaban for secondary prevention of embolic stroke of undetermined source

June 19, 2018

At a median follow-up of eleven months, rivaroxaban was not superior to aspirin for prevention of secondary stroke after an initial primary embolic stroke of undetermined source.

Prognosis of extremely premature infants linked to inherent selection bias

June 19, 2018

Demographic data, such as larger birth weight and female gender, of infants born at 23 weeks' gestation were shown to influence the chance that active resuscitation was initiated.

Medications with depression as a possible adverse effect associated with increased risk

June 15, 2018

In this cross-sectional study, the use of medications with depression as an adverse effect was associated with a higher prevalence of depression while a similar association was not observed for medications without depression as a possible side effect.

Lower and higher oxygen saturation targets result in equal but contrasting outcomes for preemies

June 14, 2018

In this meta-analysis, there was no significant difference between lower and higher oxygen saturation targets on a primary composite of mortality or major disability at a corrected age of 18-24 months for infants born extremely preterm.

No benefit of negative pressure wound therapy for lower extremity fractures

June 14, 2018

In this randomized controlled trial, there was no difference in the self-reported disability 12 months after injury between patients treated with negative pressure wound therapy (NPWT) and those treated standardardly.

Isolated mild/moderate thrombocytopenia may not require intervention

June 11, 2018

In a review of children who presented to a specialist hematology clinic with isolated mild or moderate low platelet counts, though causes were variable, most required no interventions.

Recombinant human pentraxin 2 slows the decline in lung function in idiopathic pulmonary fibrosis

June 07, 2018

The use of recombinant human pentraxin 2 vs placebo resulted in a slower decline in lung function over 28 weeks for patients with idiopathic pulmonary fibrosis.

Survey-based intervention linked to improved communication and goals-of-care discussions

June 06, 2018

Goals-of-care (GOC) discussions were linked to improved patient outcomes and reduction of intensity in end-of-life care. The current study demonstrated that a survey-based intervention for priming clinicians with communication strategies was linked to increase in the occurrence, documentation, and quality of GOC discussions.

Improved calculations suggest major changes to statin, aspirin, and blood pressure Tx

June 06, 2018

Updated risk calculations suggest that fewer people should be classified within the high-risk category for CVD.

Restrictive state alcohol policies may reduce alcohol-related crash fatalities

June 05, 2018

Increasingly restrictive state alcohol policies were associated with reduced odds that a crash fatality was alcohol related, both when blood alcohol levels were above and below the legal limit for driving in the USA (0.08%).

Early endovenous ablation of leg ulcers improves healing

June 05, 2018

Patients with leg ulcers caused by superficial venous reflux treated with compression therapy experienced earlier time to healing if they were treated with early-ablation therapy and opposed to deferred-ablation.

Viruses not linked to asthma exacerbation severity

June 04, 2018

Identified viral pathogens were not associated with asthma exacerbation severity, but were linked to increased treatment failure. Evidence Rating Level: 2 (Good).

Radial-artery grafts outperform saphenous-vein grafts when used in CABG

June 04, 2018

Patients undergoing coronary artery bypass grafting (CABG) who received a radial-artery graft rather than a saphenous-vein graft (both groups also received an internal-thoracic-artery graft) experienced fewer major adverse cardiac events at a mean follow-up of 60 months.

Surveillance of DTaP Vaccines Reveals No New Safety Concerns

June 04, 2018

Surveillance of adverse events after diphtheria-tetanus-acellular pertussis (DTaP) vaccine administration reported to the Vaccine Adverse Event Reporting System (VAERS) between 1991 and 2016 revealed no new or unexpected adverse events.

ECMO for severe ARDS does not improve mortality

May 31, 2018

Extracorporeal membrane oxygenation (ECMO) for severe acute respiratory distress syndrome (ARDS) did not show a 60-day mortality benefit compared to conventional ventilation and ECMO rescue therapy.

MRI pattern selects patients with unknown stroke time who benefit from thrombolysis

May 31, 2018

Stroke patients with unknown time of stroke onset and DWI-FLAIR mismatch indicative of a stroke within the prior 4.5 hours who were randomized to alteplase were more likely to have a favorable outcome at 90 days than those receiving placebo.

Physicians should look for misuse patterns that lead to overdose before prescribing opioids

May 29, 2018

All opioid misuse patterns examined had a positive association with opioid overdose and death.

Adolescent mothers in protective care more likely to have their children placed in care

May 29, 2018

Children born to adolescent mothers in the care of child protection services (CPS) were more likely to be taken into CPS care themselves when compared to other children in the first 2 years of life.

Safety confirmation of propranolol use in treatment of infantile hemangiomas

May 29, 2018

In healthy infants, there was no significantly increased risk for cardiovascular or metabolic events associated with propranolol use for treatment of infantile hemangioma.

Physicians report feeling moral distress over policies that force inadequate care based on immigration status

May 29, 2018

Physicians working in settings that provide emergency only hemodialysis (EOHD) reported higher rates of professional burnout.

Amyloid-beta (1-40) is a strong predictor of mortality in acute coronary syndrome

May 23, 2018

Patients with the highest Aβ40 also had the worst non-ST-segment elevation acute coronary syndrome (NSTE-ACS) risk profile.

AAP recommends life support training for general public

May 23, 2018

The Committee on Pediatric Emergency Medicine of the American Academy of Pediatrics (AAP) has published a statement in support of bystander CPR and AED training based on a review of their benefits in the public health literature.

Standard of practice intervention linked to reduced total and IV opioids for inpatients

May 22, 2018

A standard of practice and educational intervention aimed to reduce intravenous opioids in favor of subcutaneous route resulted in reduced frequency of intravenous opioids.

Long-acting buprenorphine depots may be efficacious for opioid use disorder

May 22, 2018

In this double-blind randomized controlled trial, weekly or monthly buprenorphine depot injections were non-inferior to daily sublingual buprenorphine/naloxone in maintaining no evidence of illicit opioid use at 24 weeks in outpatients with opioid use disorder (OUD).