Trial Tracker

Fremanezumab effective in preventing episodic migraine

May 17, 2018

In this randomized controlled trial, Fremanezumab slightly decreased the amount of headache free days in those with episodic migraines compared to placebo.

Acupuncture does not improve the rate of live births among in vitro fertilization

May 16, 2018

In this randomized controlled trial, administration of acupuncture at the time of ovarian stimulation and embryo transfer did not improve the rate of live births.

Children's hospital visits for suicide ideation and attempts are increasing

May 16, 2018

The percentage of patients seen at children's hospital for suicidal ideation (SI) and suicide attempts (SA) more than doubled between 2008 and 2015.

Surgical repair improves survival, pain control in patients with dementia who suffer hip fracture

May 15, 2018

In this retrospective study, nursing home patients with dementia who had a hip fracture had improved survival if they underwent surgical repair compared to non-surgical management.

Parental cannabis use increasing, cigarette use decreasing

May 14, 2018

Current cannabis use among parents with children at home increased from 4.9% to 6.8% while current cigarette use declined from 27.6% to 20.2% from 2002-2015, as measured by the National Survey on Drug Use and Health.

Postresection intravesical gemcitabine decreases non-muscle-invasive urothelial CA recurrence

May 11, 2018

In this randomized controlled trial, time to recurrence was lower in patient with non-muscle-invasive urothelial cancer when treated with intravesical gemcitabine as compared to saline controls.

Emotional regulation intervention linked to decreased high risk sexual behavior

May 10, 2018

Adolescents with no baseline sexual activity who underwent an emotional regulation sexual health intervention were less likely to report first-time vaginal or anal sex over a follow-up period of 30 months vs adolescents who underwent traditional health promotion without emotional regulation teaching.

Vasopressin plus catecholamines lowers risk of atrial fibrillation in distributive shock

May 09, 2018

In this meta-analysis, addition of vasopressin to catecholamine vasopressors was associated with a lower risk of atrial fibrillation when compared to catecholamine monotherapy.

Can coaching improve water intake, outcomes in those with chronic disease?

May 09, 2018

In this randomized controlled trial, coaching to improve daily fluid intake did not improve kidney function in patients with Chronic Kidney Disease.

Improved glycemic control in type 1 diabetics on very low-carbohydrate diets

May 08, 2018

A survey of individuals with type 1 diabetes mellitus (T1DM) consuming a very low-carbohydrate diet (VLCD) indicated that many study participants were able to maintain glycemic control within national ideal glycemic target ranges.

Hospice care may not decrease Medicare costs in patients on maintenance dialysis

May 08, 2018

In this cross-sectional study, of those patients on maintenance hemodialysis that were referred to hospice care, 41.5% received care for only 3 days or less.

Palliative care consultation linked to reduced direct hospital costs

May 08, 2018

In this meta-analysis of available studies, early palliative care consultation (PCC) for patients admitted to hospital with serious illness was associated with a reduction in direct hospital costs for that admission.

Sickle cell trait not linked to increased risk of ischemic stroke

April 27, 2018

In this meta-analysis of prospective population-based studies, sickle cell trait (SCT) was not associated with any difference in risk of first ischemic stroke.

Systematic crosschecking between emergency physicians may decrease adverse events

April 26, 2018

In this cluster randomized crossover trial, implementation of a systematic crosschecking program between two emergency physicians significantly reduced the occurrence of adverse events.

Addition of ticagrelor to aspirin significantly increased graft patency after elective CABG

April 26, 2018

In this randomized controlled trial, saphenous vein graft patency after elective CABG was significantly improved in patients treated with ticagrelor plus aspirin versus aspirin alone after one year.

Better UTI resolution with 5-day nitrofurantoin over single-dose fosfomycin

April 25, 2018

In this randomized controlled trial, women with uncomplicated urinary tract infections receiving 5-days of nitrofurantoin experienced increased clinical and microbiologic resolution at 28 days compared to single-dose fosfomycin.

Understanding in-hospital mortality after stroke in pediatric patients

April 25, 2018

Findings suggested that the rate of in-hospital mortality after pediatric stroke was 1.5% for neonates and 3.1% in children/adolescents. The authors also found that the strongest risk factors for mortality were congenital heart disease and stroke that involved both anterior and posterior circulation.

Elevated FGF-23 associated with recurrent cardiovascular events after acute coronary syndrome

April 25, 2018

Elevated FGF-23 concentration was associated with increased risk of adverse cardiovascular (CV) outcomes, including CV death and heart failure hospitalization.

Sigmoidoscopy reduces colon cancer risk for men, but not women

April 24, 2018

Sigmoidoscopy was associated with a reduction in the prevalence of colon cancer mortality in men.

Rustbelt states may have greatest racial disparities between for firearm homicides

April 24, 2018

Racial disparities for firearm homicides between black and white males are highest in Illinois, Indiana, Michigan, Missouri, and Pennsylvania, with higher rates for black males.

SGLT-2 inhibitors and GLP-1 agonists associated with better mortality outcomes than DPP-4 inhibitors for T2D

April 20, 2018

SGLT-2 or GLP-1 agonists were associated with lower mortality than DPP-4 inhibitors, placebo, or no treatment.

Intensive LDL-C lowering reduces mortality in patients with higher baseline LDL-C

April 20, 2018

In this systematic review and meta-analysis, more intensive compared with less itensive LDL-C lowering was associated with a greater reduction in risk of total and cardiovascular mortality in trials of patients with higher baseline LDL-C levels.

Centrifugal-flow pumps improve complication free survival compared to axial flow-pumps

April 19, 2018

Advanced heart failure patients randomized to receive centrifugal-flow pumps demonstrated higher rates of 2-year survival free of disabling stroke or reoperation to remove or replace their device compared to patients randomized to receive axial-flow pumps.

Optimizing organ donations from overdose deaths may help address national organ shortage

April 19, 2018

U.S. transplants using organs from overdose-death donors (ODDs) has increased 24-fold from 2000 to 2016, and transplant outcomes from organs donated by ODDs have been noninferior to those donated by trauma-death donors (TDDs) and medical-death donors (MDDs).

Higher short-term mortality demonstrated for women compared with men after STEMI

April 18, 2018

In a modern cohort of patients with readily available primary percutaneous coronary intervention, woman experienced greater mortality rates then men following ST-elevation myocardial infarction.

Medicare pre-ESRD care results in more dialysis initiation but also increased two-year mortality

April 18, 2018

Veterans receiving pre-end stage renal disease (ESRD) nephrology care in under the Medicare system were more likely to undergo dialysis and had a higher two-year mortality rate than veterans that received pre-ESRD care through the Department of Veteran's Affairs (VA).

Prevalence of cerebral palsy in preterm infants changes over time

April 17, 2018

In preterm infants followed over a 3.75-year study period, the overall prevalence of cerebral palsy (CP) decreased from 16% to 12%, the prevalence of severe CP decreased from 26% to 16%, but the prevalence of mild CP increased from 39% to 43%.

Inhibiting mitochondrial responses after intra-articular fracture slows progression of posttraumatic osteoarthritis

April 13, 2018

Intra-articular fractures (IAFs) often lead to posttraumatic osteoarthritis (PTOA) through mechanisms that involve mitochondria.

BEACON CRC Safety Lead-in Study suggests safety and efficacy of triplet combo Tx metastatic colorectal CA

April 13, 2018

BEACON CRC is a multicenter, randomized, phase 3 clinical trial evaluating the triplet combination of binimetinib (BINI, a MEK inhibitor) + encorafenib (ENCO, a BRAF inhibitor) + cetuximab (CETUX, an EGFR antibody) for the treatment of metastatic colorectal cancer.

Emergency department revisit rates underestimated among pediatric patients

April 12, 2018

Emergency department (ED) revisit rates among pediatric patients were shown to be underestimated by almost 20% when only revisits that occurred at the same hospital as the original visit were considered.