Trial Tracker

Secnidazole Treatment of Bacterial Vaginosis: A Randomized Controlled Trial

August 01, 2017

Hillier, SL et al. "Secnidazole Treatment of Bacterial Vaginosis: A Randomized Controlled Trial." DOI: 10.1097/AOG.0000000000002135

Abiraterone Plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer

By July 27, 2017

Fizazi, K et al. "Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer." DOI: 10.1056/NEJMoa1704174

Tremelimumab as Second, Third-Line Tx in Relapsed Malignant Mesothelioma

By July 17, 2017

Maio, M et al. "Tremelimumab as second-line or third-line treatment in relapsed malignant mesothelioma (DETERMINE): a multicentre, international, randomised, double-blind, placebo-controlled phase 2b trial." DOI: http://dx.doi.org/10.1016/S1470-2045(17)30446-1

Ebselen Examined for Prevention of Noise-Induced Hearing Loss

By July 14, 2017

Kil, J et al. "Safety and efficacy of ebselen for the prevention of noise-induced hearing loss: a randomised, double-blind, placebo-controlled, phase 2 trial." DOI: http://dx.doi.org/10.1016/S0140-6736(17)31791-9

Biosimilar Compared to Rituximab in Untreated Advanced-Stage Follicular Lymphoma

By July 13, 2017

Kim, WS et al. "Efficacy, pharmacokinetics, and safety of the biosimilar CT-P10 compared with rituximab in patients with previously untreated advanced-stage follicular lymphoma: a randomised, double-blind, parallel-group, non-inferiority phase 3 trial." DOI: http://dx.doi.org/10.1016/S2352-3026(17)30120-5

Efficacy of Lisdexamfetamine in Moderate to Severe Binge-Eating Disorder

July 12, 2017

Hudson, JI et al. "Efficacy of Lisdexamfetamine in Adults With Moderate to Severe Binge-Eating Disorder: A Randomized Clinical Trial." DOI: 10.1001/jamapsychiatry.2017.1889

Idarucizumab for Dabigatran Reversal — Full Cohort Analysis

By July 11, 2017

Pollack, CV et al. "Idarucizumab for Dabigatran Reversal — Full Cohort Analysis." DOI: 10.1056/NEJMoa1707278

Adverse Event Profile of Inotuzumab Ozogamicin in Relapsed/Refractory ALL

By July 04, 2017

Kantarjian, HM et al. "Hepatic adverse event profile of inotuzumab ozogamicin in adult patients with relapsed or refractory acute lymphoblastic leukaemia: results from the open-label, randomised, phase 3 INO-VATE study." DOI: http://dx.doi.org/10.1016/S2352-3026(17)30103-5

Effects of Insulin Degludec vs Glargine U100 on Hypoglycemia in T2D

By July 04, 2017

Wysham, C et al. "Effect of Insulin Degludec vs Insulin Glargine U100 on Hypoglycemia in Patients With Type 2 Diabetes." DOI: 10.1001/jama.2017.7117

Effect of Insulin Degludec vs Glargine U100 on Hypoglycemia in T1D

By July 04, 2017

Lane, W et al. "Effect of Insulin Degludec vs Insulin Glargine U100 on Hypoglycemia in Patients With Type 1 Diabetes." DOI: 10.1001/jama.2017.7115

Combo Tofacitinib Plus Methotrexate vs Adalimumab Plus Methorexate Tx

By June 30, 2017

Fleischmann, R et al. "Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a phase 3b/4, double-blind, head-to-head, randomised controlled trial." DOI: http://dx.doi.org/10.1016/S0140-6736(17)31618-5

Single-Tablet Elvitegravir, Cobicistat, Emtricitabine, & Tenofovir Alafenamide in Virologic Suppressed Children with HIV

By June 29, 2017

Natukunda, E et al. "Safety, efficacy, and pharmacokinetics of single-tablet elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide in virologically suppressed, HIV-infected children: a single-arm, open-label trial." DOI: http://dx.doi.org/10.1016/S2352-4642(17)30009-3

Electrical Direct-Current Therapy vs. Escitalopram in Depression

June 29, 2017

Brunoni, AR et al. "Trial of Electrical Direct-Current Therapy versus Escitalopram for Depression." DOI: 10.1056/NEJMoa1612999

A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses

By June 29, 2017

Daum, RS et al. "A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses." DOI: 10.1056/NEJMoa1607033

Rituximab Plus Autologous Stem-Cell Transplant in Diffuse Large B-Cell Lymphoma

By June 28, 2017

Chiappella, A et al. "Rituximab-dose-dense chemotherapy with or without high-dose chemotherapy plus autologous stem-cell transplantation in high-risk diffuse large B-cell lymphoma (DLCL04): final results of a multicentre, open-label, randomised, controlled, phase 3 study." DOI: http://dx.doi.org/10.1016/S1470-2045(17)30444-8

Inactivated Influenza Vaccine Delivered by Microneedle Patch

By June 27, 2017

Rouphael, NG et al. "The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial." DOI: http://dx.doi.org/10.1016/S0140-6736(17)30575-5

Empagliflozin Effects on the Urinary Albumin-to-Creatinine Ratio in T2D, Heart Disease Patients

By June 27, 2017

Cherney, DZ et al. "Effects of empagliflozin on the urinary albumin-to-creatinine ratio in patients with type 2 diabetes and established cardiovascular disease: an exploratory analysis from the EMPA-REG OUTCOME randomised, placebo-controlled trial." DOI: http://dx.doi.org/10.1016/S2213-8587(17)30182-1

Bioequivalence Between Generic, Branded Lamotrigine in People With Epilepsy

By June 26, 2017

Berg, M et al. "Bioequivalence Between Generic and Branded Lamotrigine in People With Epilepsy." DOI: 10.1001/jamaneurol.2017.0497

Azithromycin on Asthma Exacerbations, QoL in Persistent Uncontrolled Asthma

By June 26, 2017

Gibson, PG et al. "Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial." DOI: http://dx.doi.org/10.1016/S0140-6736(17)31281-3

Doxorubicin + Evofosfamide vs. Doxorubicin Alone in Soft-Tissue Sarcoma

By June 23, 2017

Tap, WD et al. "Doxorubicin plus evofosfamide versus doxorubicin alone in locally advanced, unresectable or metastatic soft-tissue sarcoma (TH CR-406/SARC021): an international, multicentre, open-label, randomised phase 3 trial." DOI: http://dx.doi.org/10.1016/S1470-2045(17)30381-9

Midostaurin Plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

By June 23, 2017

Stone, RM et al. "Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation." DOI: 10.1056/NEJMoa1614359

Effect of Buprenorphine and Hydromorphone Blockade in Opioid Use Disorder

By June 22, 2017

Walsh, SL et al. "Effect of Buprenorphine Weekly Depot (CAM2038) and Hydromorphone Blockade in Individuals With Opioid Use Disorder." DOI: 10.1001/jamapsychiatry.2017.1874

Efficacy of Recombinant Influenza Vaccine in Patients ≥50

By June 22, 2017

Dunkle, LM et al. "Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older." DOI: 10.1056/NEJMoa1608862

First-Line Nivolumab in Stage IV or Recurrent NSCLC

By June 22, 2017

Carbone, DP et al. "First-Line Nivolumab in Stage IV or Recurrent Non-Small-Cell Lung Cancer." DOI: 10.1056/NEJMoa1613493

Rituximab Biosimilar Assessed in Combo with Methotrexate in Active Rheumatoid Arthritis

By June 21, 2017

Smolen, JS et al. "A randomised, double-blind trial to demonstrate bioequivalence of GP2013 and reference rituximab combined with methotrexate in patients with active rheumatoid arthritis." DOI: http://dx.doi.org/10.1136/annrheumdis-2017-211281

Once vs Twice-Daily Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer

By June 19, 2017

Faivre-Finn, C et al. "Concurrent once-daily versus twice-daily chemoradiotherapy in patients with limited-stage small-cell lung cancer (CONVERT): an open-label, phase 3, randomised, superiority trial." DOI: http://dx.doi.org/10.1016/S1470-2045(17)30318-2

A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis

By June 15, 2017

Le, T et al. "A Trial of Itraconazole or Amphotericin B for HIV-Associated Talaromycosis." DOI: 10.1056/NEJMoa1613306

Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome

By June 15, 2017

Kraft, WK et al. "Buprenorphine for the Treatment of the Neonatal Abstinence Syndrome." DOI: 10.1056/NEJMoa1614835

Algorithm Assessed for Early Diagnosis of Pulmonary Arterial Hypertension in Systemic Sclerosis

By June 14, 2017

Guillén-Del Castillo, A et al. "High sensitivity and negative predictive value of the DETECT algorithm for an early diagnosis of pulmonary arterial hypertension in systemic sclerosis: application in a single center." DOI: 10.1186/s13075-017-1327-8

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

By June 12, 2017

Neal, B et al. "Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes." DOI: 10.1056/NEJMoa1611925