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TRENTAL
Intermittent claudication
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Drug Name:

TRENTAL Rx

Generic Name and Formulations:
Pentoxifylline 400mg; sust rel tabs.

Company:
Sanofi Aventis

e-Prescribe this drug via Surescripts


Therapeutic Use:

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RECENT UPDATES

12/21/12
Updated Warn/Precs in patients with hemorrhagic risk factors.

Indications for TRENTAL:

Intermittent claudication.

Adult Dose for TRENTAL:

400mg three times daily with meals. Continue for at least 8 wks. Digestive or CNS effects: lower dosage to 400mg twice daily; discontinue if side effects persist.

Children's Dose for TRENTAL:

Not established.

Pharmacological Class:

Hemorrheologic agent (xanthine).

Contraindications:

Recent cerebral or retinal hemorrhage. Methylxanthines intolerance (eg, caffeine, theophylline, theobromine).

Warnings/Precautions:

Discontinue if anaphylactic/anaphylactoid reaction occurs. Monitor for bleeding including hematocrit, hemoglobin in patients with hemorrhagic risk factors (eg, recent surgery, peptic ulcer, cerebral and/or retinal bleeding). Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See Contraindications. May potentiate antihypertensives; monitor BP. Concomitant theophylline-containing drugs; monitor closely and adjust dose. Concomitant warfarin; monitor PT frequently.

Adverse Reactions:

GI upset, nausea, dyspepsia, headache, dizziness, insomnia, blurred vision.

Metabolism:

Hepatic.

Elimination:

Renal (primarily), fecal.

Generic Availability:

YES

How Supplied:

Tabs—100