400mg three times daily with meals. Continue for at least 8 wks. Digestive or CNS effects: lower dosage to 400mg twice daily; discontinue if side effects persist.
Hemorrheologic agent (xanthine).
Recent cerebral or retinal hemorrhage. Methylxanthines intolerance (eg, caffeine, theophylline, theobromine).
Discontinue if anaphylactic/anaphylactoid reaction occurs. Monitor for bleeding including hematocrit, hemoglobin in patients with hemorrhagic risk factors (eg, recent surgery, peptic ulcer, cerebral and/or retinal bleeding). Pregnancy (Cat.C). Nursing mothers: not recommended.
See Contraindications. May potentiate antihypertensives; monitor BP. Concomitant theophylline-containing drugs; monitor closely and adjust dose. Concomitant warfarin; monitor PT frequently.
GI upset, nausea, dyspepsia, headache, dizziness, insomnia, blurred vision.
Renal (primarily), fecal.