TRADJENTA Rx

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TRADJENTA

Diabetes
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Generic Name and Formulations:

Linagliptin 5mg; tabs.

Select therapeutic use:

Indications for TRADJENTA:

Adjunct to diet and exercise in type 2 diabetes mellitus, as monotherapy or combination therapy.

Limitations Of use:

Not for treatment of type 1 diabetes or diabetic ketoacidosis. Not studied in patients with a history of pancreatitis.

Adult:

5mg once daily.

Children:

<18yrs: not established.

Warnings/Precautions:

Monitor for signs/symptoms of pancreatitis, serious hypersensitivity reactions, or severe joint pain; discontinue if suspected or occurs. History of angioedema to other DPP-4 inhibitors. Pregnancy (Cat.B). Nursing mothers.

Interactions:

Antagonized by strong P-gp or CYP3A4 inducers (eg, rifampin); consider alternatives to linagliptin if used in combination. May need lower dose of concomitant sulfonylurea or insulin to reduce risk of hypoglycemia.

Pharmacological Class:

Dipeptidyl peptidase-4 (DPP-4) inhibitor.

Adverse Reactions:

Nasopharyngitis, diarrhea, cough, hypoglycemia; hypersensitivity reactions (eg, anaphylaxis, urticaria, angioedema, exfoliative skin conditions, bronchial hyperreactivity), myalgia, pancreatitis, severe and disabling arthralgia.

Metabolism:

Extensively unchanged.

Elimination:

Enterohepatic (80%), renal (5%).

Generic Availability:

NO

How Supplied:

Tabs—30, 90

TRADJENTA 5mg tablets (Qty:30)

appx. price $367.00