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TOVIAZ
Overactive bladder/enuresis
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Drug Name:

TOVIAZ Rx

Generic Name and Formulations:
Fesoterodine fumarate 4mg, 8mg; ext-rel tabs.

Company:
Pfizer Inc.



Therapeutic Use:

Indications for TOVIAZ:

Overactive bladder (OAB) with urge urinary incontinence, urgency, and frequency.

Adult Dose for TOVIAZ:

Swallow whole. 4mg once daily; max 8mg once daily. Severe renal insufficiency (CrCl<30mL/min) or concomitant potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin): max 4mg/day.

Children's Dose for TOVIAZ:

Not recommended.

Pharmacological Class:

Muscarinic receptor antagonist.

Contraindications:

Urinary or gastric retention. Uncontrolled narrow angle glaucoma.

Warnings/Precautions:

Severe hepatic impairment: not recommended. Discontinue promptly if angioedema with upper airway swelling occurs. Bladder outlet obstruction. Controlled narrow angle glaucoma. Hepatic or renal dysfunction. Myasthenia gravis. Decreased gastric motility. Monitor for CNS effects after treatment initiation or dose increases; consider dose reduction or discontinuation if occur. Exposure to high environmental temperatures. Pregnancy (Cat.C). Nursing mothers.

Interactions:

See Adult dose. Increased levels with potent CYP3A4 inhibitors (eg, ketoconazole, itraconazole, clarithromycin). Additive effects with other antimuscarinic or anticholinergic agents. Monitor with warfarin.

Adverse Reactions:

Dry mouth, constipation, urinary retention/UTI, blurred vision, dry eyes, back pain, insomnia, dyspepsia, cough; CNS effects (eg, dizziness, headache, somnolence).

Metabolism:

Hepatic (CYP2D6, CYP3A4).

Elimination:

Renal (primarily), fecal.

Generic Availability:

NO

How Supplied:

Tabs—30, 90

TOVIAZ

  • 8mg tablets (Qty:30)
  • appx. price $205.00
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