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Cytoprotective and supportive care agents
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Generic Name and Formulations:

Dexrazoxane 500mg; per vial; pwd for IV infusion after reconstitution and dilution; preservative-free.


Biocodex USA

Select therapeutic use:

Indications for TOTECT:

To treat extravasation resulting from IV anthracycline chemotherapy.


Give once daily for 3 consecutive days by IV infusion over 1–2 hours. Initiate 1st dose as soon as possible and within 1st 6 hours after extravasation. Days 1 and 2: 1000mg/m2; max 2000mg. Day 3: 500mg/m2; max 1000mg. Renal impairment (CrCl <40mL/min): reduce dose by 50%.


Not recommended.


Renal or hepatic impairment (monitor liver enzymes). Monitor for myelosuppression; obtain blood counts periodically. Elderly. Labor & delivery. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.


Avoid dimethylsulfoxide (DMSO). Caution with concurrent cytotoxic chemotherapy (additive cytotoxicity).

Pharmacological Class:

Detoxifying agent.

Adverse Reactions:

Inj site reactions, GI upset, stomatitis, leukopenia, neutropenia, thrombocytopenia, elevated liver enzymes, pyrexia, infections.

How Supplied:

Kit—10 single-use vials (w. diluent)