TOFRANIL
Generic Name for TOFRANIL
Imipramine HCl 10mg, 25mg, 50mg; tabs.
Legal Classification:
Rx
Pharmacological Class for TOFRANIL
Anticholinergic.
Manufacturer of TOFRANIL
Mallinckrodt, Inc.
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Indications for TOFRANIL
Childhood enuresis.
Children's dosing for TOFRANIL
<6 years: not recommended. ≥6 years: initially 25 mg daily 1 hour before bedtime; after 1 week, increase to 50 mg for children 6–12 years, up to 75 mg for those >12 years. Early night bedwetters: give 25 mg in afternoon and repeat at bedtime. Max 2.5 mg/kg per day. Attempt drug-free periods after gradual tapering of dose if drug response favorable.
Contraindications for TOFRANIL
During or within 14 days of MAOIs. Acute post-MI.
Precautions for TOFRANIL
Obstructive uropathies. Glaucoma. Cardiovascular disease. Monitor ECG. Epilepsy. Suicidal tendencies. Psychosis. Mania/hypomania. Hyperthyroidism. Diabetes. Renal or hepatic dysfunction. Pregnancy (Cat.C). Nursing mothers: not recommended.
Interactions for TOFRANIL
Hyperpyretic crisis, convulsions, death with MAOIs. Potentiates alcohol, sympathomimetics, CNS depressants. Potentiated by methylphenidate, CYP2D6 inhibitors; monitor plasma levels with cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, quinidine). Antagonized by barbiturates, carbamazepine, phenytoin. Paralytic ileus, hyperpyrexia with anticholinergics. Increased cardiovascular effects with methylphenidate. Blocks guanethidine, clonidine.
Adverse Reactions for TOFRANIL
Drowsiness, orthostatic hypotension, ECG changes, restlessness, insomnia, anticholinergic effects, CNS overstimulation, extrapyramidal symptoms, nausea, fatigue, rash, headache, changes in blood sugar, photosensitivity, edema, bone marrow depression (discontinue if occurs), jaundice, urinary frequency.
How is TOFRANIL supplied?
Tabs—100
Related Disease:
Enuresis