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TOFRANIL
Mood disorders
Overactive bladder/enuresis
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Drug Name:

TOFRANIL Rx

Generic Name and Formulations:
Imipramine HCl 10mg, 25mg, 50mg; tabs.

Company:
Mallinckrodt, Inc.

e-Prescribe this drug via Surescripts


Therapeutic Use:

Indications for TOFRANIL:

Depression.

Adult Dose for TOFRANIL:

Initially 75mg/day; max 200mg/day. Adolescents or elderly: initially 30–40mg/day; max 100mg/day.

Children's Dose for TOFRANIL:

Not established.

See Also:

TOFRANIL-PM

Pharmacological Class:

Tricyclic.

Contraindications:

During or within 14 days of MAOIs. Concomitant linezolid or IV methylene blue. Acute post-MI.

Warnings/Precautions:

Suicidal ideation (monitor). Urinary retention. Glaucoma. Cardiovascular disease. Epilepsy. ECT. Psychosis. Mania/hypomania. Bipolar disorder. Diabetes. Hyperthyroidism. Renal or hepatic disorders. Write Rx for smallest amount feasible. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hyperpyretic crisis, convulsions, death with MAOIs. Serotonin syndrome possible with concomitant triptans, tricyclics, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's wort, linezolid, IV methylene blue. Potentiates alcohol, sympathomimetics, CNS depressants. Potentiated by methylphenidate, CYP2D6 inhibitors; monitor plasma levels with cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, quinidine). Antagonized by barbiturates, carbamazepine, phenytoin. Paralytic ileus, hyperpyrexia with anticholinergics. Increased cardiovascular effects with methylphenidate. Blocks guanethidine, clonidine.

Adverse Reactions:

Drowsiness, anticholinergic effects, CNS overstimulation, arrhythmias, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, increased perspiration, headache, changes in blood sugar, photosensitivity, edema, blood dyscrasias (discontinue if occurs), jaundice.

How Supplied:

Tabs—100; Caps—30

Indications for TOFRANIL:

Childhood enuresis.

Children's Dose for TOFRANIL:

<6yrs: not recommended. ≥6yrs: initially 25mg daily 1 hour before bedtime; after 1 week, increase to 50mg for children 6–12yrs, up to 75mg for those >12yrs. Early night bedwetters: give 25mg in afternoon and repeat at bedtime. Max 2.5mg/kg per day. Attempt drug-free periods after gradual tapering of dose if drug response favorable.

See Also:

Pharmacological Class:

Anticholinergic.

Contraindications:

During or within 14 days of MAOIs. Concomitant linezolid or IV methylene blue. Acute post-MI.

Warnings/Precautions:

Suicidal ideation (monitor). Obstructive uropathies. Glaucoma. Cardiovascular disease. Monitor ECG. Epilepsy. Psychosis. Mania/hypomania. Hyperthyroidism. Diabetes. Renal or hepatic dysfunction. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Hyperpyretic crisis, convulsions, death with MAOIs. Serotonin syndrome possible with concomitant triptans, tricyclics, fentanyl, lithium, tramadol, tryptophan, buspirone, St. John's wort, linezolid, IV methylene blue. Potentiates alcohol, sympathomimetics, CNS depressants. Potentiated by methylphenidate, CYP2D6 inhibitors; monitor plasma levels with cimetidine, SSRIs, phenothiazines, type 1C antiarrhythmics (eg, quinidine). Antagonized by barbiturates, carbamazepine, phenytoin. Paralytic ileus, hyperpyrexia with anticholinergics. Increased cardiovascular effects with methylphenidate. Blocks guanethidine, clonidine.

Adverse Reactions:

Drowsiness, orthostatic hypotension, ECG changes, restlessness, insomnia, anticholinergic effects, CNS overstimulation, extrapyramidal symptoms, nausea, fatigue, rash, headache, changes in blood sugar, photosensitivity, edema, bone marrow depression (discontinue if occurs), jaundice, urinary frequency.

How Supplied:

Tabs—100

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