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Generic Name and Formulations:

Timolol maleate 0.25%, 0.5%; oph gel forming soln.

Select therapeutic use:

Indications for TIMOPTIC-XE:

Elevated intraocular pressure in ocular hypertension or open-angle glaucoma.


Invert closed bottle and shake once before each use. 1 drop once daily. Give other oph. drugs at least 10 minutes before.


Not established.


Greater than 1st-degree AV block. Uncompensated cardiac failure. Cardiogenic shock. Sinus bradycardia. History of bronchospasm. Bronchial asthma. Severe COPD.


Not for use as sole agent in angle-closure glaucoma. Poor cardiac reserve should be controlled with digitalis and diuretics. Diabetes. Presbyopia. May mask hypoglycemia or thyrotoxicosis. Myasthenia gravis. Cerebrovascular insufficiency. Measure intraocular pressure after 4 weeks of treatment. Avoid abrupt cessation. Discontinue at 1st sign of cardiac failure and before surgery. Pregnancy. Nursing mothers: not recommended.


May potentiate systemic β-blockers, reserpine, hypoglycemics and mydriatic effect of topical epinephrine. Additive cardiac and pulmonary effects with anticholinesterase miotics. May antagonize bronchodilation from β-adrenergic agonists. May cause conduction defects with calcium channel blockers, digoxin. May be potentiated by CYP2D6 inhibitors (eg, quinidine, SSRIs).

See Also:

Timolol Maleate


Pharmacological Class:

Noncardioselective beta-blocker.

Adverse Reactions:

Ocular irritation, sensitization, rash, dizziness, blurred vision, corneal anesthesia, headache, GI upset, paresthesias. Systemic β-blocker effects (bradycardia, arrhythmias, hypotension, bronchospasm, heart failure). Aphakic maculopathy (rare).

Generic Availability:


How Supplied:

Soln—contact supplier; Ocudose—60; XE—2.5mL, 5mL

TIMOPTIC-XE 5ml of 0.5% bottle of gels (Qty:2)

appx. price $439.00